Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion

Dan Atar, Victor Serebruany, Jay Poulton, Joel Godard, Alan Schneider, William R. Herzog

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2 +) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregation would be elicited. An open-chest model was used, with transient occlusion of the left anterior descending coronary artery (LAD) for 8 min. Regional contractile function was assessed by measuring wall thickening fraction with epicardial Doppler crystals. One control group (n = 6) and two treatment groups were studied: Group I (n = 6) received 750 mg MgSO4 before occlusion; group II (n = 6) received I g MgSO4 after the occlusion. Both protocols produced significant hypermagnesemia. In group I, platelet aggregation was measured before and after Mg2 + treatment using platelet-rich plasma (PRP) and various agonists (ADP 5 and 10 mM and collagen I mg/ml). As compared with controls, both treatment groups experienced significantly less postischemic dysfunction, with systolic function returning more quickly to baseline. Furthermore, platelet aggregation was significantly decreased immediately after Mg2+ infusion. Inhibition of platelet aggregation induced by Mg2+ treatment occurs concomitantly with significant amelioration of postischemic myocardial dysfunction.

Original languageEnglish (US)
Pages (from-to)603-611
Number of pages9
JournalJournal of cardiovascular pharmacology
Volume24
Issue number4
DOIs
StatePublished - Oct 1994

Keywords

  • Animal model
  • Contractile dysfunction
  • Magnesium
  • Myocardial stunning
  • Platelet aggregability

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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