Effects of lung volume on collateral and airways resistance in man

C. R. Inners, Peter Browne Terry, R. J. Traystman, H. A. Menkes

Research output: Contribution to journalArticle

Abstract

The effects of changing lung volume (VL) on collateral resistance (Rcoll) and total airways resistance (Raw) were compared in six young volunteers. At functional residual capacity (FRC) = 55% total lung capacity (TLC), mean Rcoll was 4,664 ± 1,518 (SE) cmH2O/(l/s) and mean Raw was 1.57 ± 0.11 (SE) cmH2O/(l/s). When VL increased to 80% TLC, Rcoll decreased by 63.3 ± 7.8%, and Raw decreased by 50.3 ± 4.2 (SE) %. The decrease in Rcoll with increasing lung volume was not statistically different from that of Raw (P > 0.05). If the airways obstructed for measurements of Rcoll served between 2 and 5% of the lungs, then Rcoll was approximately 50 times as great as the resistance to flow through airways serving the same volume of lung at FRC. This relationship did not change significantly when VL increased by 25% TLC. If changes in Raw reflect changes in airways supplying sublobar portions of lung, these results indicate that there is no tendency for the redistribution of ventilation through airways and collateral pathways with changes in VL in young subjects.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume46
Issue number1
StatePublished - 1979

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Airway Resistance
Total Lung Capacity
Lung
Functional Residual Capacity
Ventilation
Volunteers

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Effects of lung volume on collateral and airways resistance in man. / Inners, C. R.; Terry, Peter Browne; Traystman, R. J.; Menkes, H. A.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 46, No. 1, 1979, p. 67-73.

Research output: Contribution to journalArticle

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