Effects of ionic concentrations on propagation speed in myocardium

A. Feldman, Y. B. Chernyak, R. J. Cohen

Research output: Contribution to journalConference articlepeer-review

Abstract

We used our recently developed membrane model to calculate the dependence of propagation speed on shifts in the membrane's current-voltage (I-V) relation caused by changes in the ionic environment. These shifts can be linked analytically to changes in the concentrations of cations such as Ca++ and H+. We calculated the propagation speed using the reaction-diffusion equation for the membrane potential and obtained a value of 55 cm/s for myocardium at standard ionic concentrations. This value varied between 12 cm/s and 85 cm/s for shifts between +46 mV and -14 mV, respectively.

Original languageEnglish (US)
Pages (from-to)21-22
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume17
Issue number1
StatePublished - Dec 1 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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