Effects of intravenous caffeine administered to healthy males during sleep

Albert Shi Kwang Lin, Thomas W. Uhde, Shiyoko O. Slate, Una D McCann

Research output: Contribution to journalArticle

Abstract

Pharmacological challenge paradigms have been useful for elucidating the phenomenology and neurobiology of panic attacks. A drawback of the pharmacological challenge method is that individual differences in baseline arousal and outcome expectancy can lead to different subjective and physiological drug responses. One method for eliminating differences in baseline arousal and expectancy is to perform pharmacological challenges during non-rapid eye movement (non-REM) sleep. In the present study, fourteen healthy male volunteers received caffeine (5 mg/kg) and placebo (normal saline) during non-REM sleep on two successive nights, in a single-blind manner. Caffeine, compared to placebo, was associated with increased arousal, sleep disruption, and elevations in adrenocorticotropic hormone (ACTH) and cortisol. In one subject, caffeine infusion during sleep induced a panic attack. These findings indicate that caffeine leads to increased arousal and hypothalamic-pituitary-adrenal axis (HPA) axis activation in the absence of high baseline anxiety and expectancy bias. Further, they suggest that similar techniques can be employed in patient populations to elucidate the neurobiology of sleep panic attacks.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalDepression and Anxiety
Volume5
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Caffeine
Sleep
Arousal
Panic Disorder
Neurobiology
Pharmacology
Eye Movements
Placebos
Individuality
Adrenocorticotropic Hormone
Hydrocortisone
Healthy Volunteers
Anxiety
Pharmaceutical Preparations
Population

Keywords

  • Anxiety
  • Arousal
  • Panic attacks
  • Pharmacological challenge
  • Sleep panic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Effects of intravenous caffeine administered to healthy males during sleep. / Lin, Albert Shi Kwang; Uhde, Thomas W.; Slate, Shiyoko O.; McCann, Una D.

In: Depression and Anxiety, Vol. 5, No. 1, 1997, p. 21-28.

Research output: Contribution to journalArticle

Lin, Albert Shi Kwang ; Uhde, Thomas W. ; Slate, Shiyoko O. ; McCann, Una D. / Effects of intravenous caffeine administered to healthy males during sleep. In: Depression and Anxiety. 1997 ; Vol. 5, No. 1. pp. 21-28.
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