Effects of Intraocular Bubble Duration in the Treatment of Macular Holes by Vitrectomy and Transforming Growth Factor-beta 2

John T. Thompson; Bert M. Glaser; Raymond N. Sjaarda; Robert P. Murphy; Ann Hanham

doi:10.1016/S0161-6420(94)31187-0

Effects of Intraocular Bubble Duration in the Treatment of Macular Holes by Vitrectomy and Transforming Growth Factor-beta 2

John T. Thompson, Bert M. Glaser, Raymond N. Sjaarda, Robert P. Murphy, Ann Hanham

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Purpose: To compare the effect of a long-acting (16% perfluoropropane [C₃F₈]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-β₂) on the macula. Methods: Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-β₂ was performed in 15 eyes treated with air and 37 eyes treated with 16% C₃F₈ using identical surgical techniques (mean follow-up, 5.6 months). Results: The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C₃F₈ and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C₃F₈ and 1.3 lines for eyes treated with air (P = 0.003). Conclusions: A longer duration intraocular gas tamponade from 16% C₃F₈ gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-β₂ than does air.

Original language	English (US)
Pages (from-to)	1195-1200
Number of pages	6
Journal	Ophthalmology
Volume	101
Issue number	7
DOIs	https://doi.org/10.1016/S0161-6420(94)31187-0
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Effects of Intraocular Bubble Duration in the Treatment of Macular Holes by Vitrectomy and Transforming Growth Factor-beta 2",

abstract = "Purpose: To compare the effect of a long-acting (16% perfluoropropane [C3F8]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-β2) on the macula. Methods: Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-β2 was performed in 15 eyes treated with air and 37 eyes treated with 16% C3F8 using identical surgical techniques (mean follow-up, 5.6 months). Results: The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C3F8 and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C3F8 and 1.3 lines for eyes treated with air (P = 0.003). Conclusions: A longer duration intraocular gas tamponade from 16% C3F8 gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-β2 than does air.",

author = "Thompson, {John T.} and Glaser, {Bert M.} and Sjaarda, {Raymond N.} and Murphy, {Robert P.} and Ann Hanham",

year = "1994",

doi = "10.1016/S0161-6420(94)31187-0",

language = "English (US)",

volume = "101",

pages = "1195--1200",

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T1 - Effects of Intraocular Bubble Duration in the Treatment of Macular Holes by Vitrectomy and Transforming Growth Factor-beta 2

AU - Thompson, John T.

AU - Glaser, Bert M.

AU - Sjaarda, Raymond N.

AU - Murphy, Robert P.

AU - Hanham, Ann

PY - 1994

Y1 - 1994

N2 - Purpose: To compare the effect of a long-acting (16% perfluoropropane [C3F8]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-β2) on the macula. Methods: Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-β2 was performed in 15 eyes treated with air and 37 eyes treated with 16% C3F8 using identical surgical techniques (mean follow-up, 5.6 months). Results: The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C3F8 and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C3F8 and 1.3 lines for eyes treated with air (P = 0.003). Conclusions: A longer duration intraocular gas tamponade from 16% C3F8 gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-β2 than does air.

AB - Purpose: To compare the effect of a long-acting (16% perfluoropropane [C3F8]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-β2) on the macula. Methods: Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-β2 was performed in 15 eyes treated with air and 37 eyes treated with 16% C3F8 using identical surgical techniques (mean follow-up, 5.6 months). Results: The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C3F8 and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C3F8 and 1.3 lines for eyes treated with air (P = 0.003). Conclusions: A longer duration intraocular gas tamponade from 16% C3F8 gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-β2 than does air.

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Effects of Intraocular Bubble Duration in the Treatment of Macular Holes by Vitrectomy and Transforming Growth Factor-beta 2

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