Effects of intestinal electrical stimulation on intestinal dysrhythmia and symptoms in dogs

Jinsong Liu, Lijie Wang, J. D.Z. Chen

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the effect of intestinal electrical stimulation on small intestinal dysrhythmia and motion sickness-like symptoms induced by vasopressin. Female dogs chronically implanted with two pairs of electrodes on jejunum serosa were used in a four-session study. Saline and vasopressin were infused in sessions 1 and 2, respectively. Sessions 3 and 4 were the same as session 2, except a long- or short-pulse intestinal electrical stimulation was applied on the proximal pair of electrodes. Intestinal slow waves and motion sickness-like symptoms were recorded in each session. Results were as follows. (1) Vasopressin induced intestinal dysrhythmia, uncoupling of slow waves, and vomiting and motion sickness-like symptoms (P<0.05, ANOVA). (2) Intestinal electrical stimulation with long pulses, but not short pulses, was capable of preventing vasopressin-induced intestinal dysrhythmia. (3) Intestinal electrical stimulation with short pulses, but not long pulses, prevented vomiting and the motion sickness-like symptoms. It is concluded that vasopressin induces intestinal dysrhythmia. Long-pulse intestinal stimulation normalizes vasopressin-induced intestinal slow-wave abnormalities with no improvement in symptoms. Short-pulse stimulation prevents emetic symptoms induced by vasopressin but has no effect on slow waves. These data suggest different mechanisms involved with different methods of intestinal stimulation.

Original languageEnglish (US)
Pages (from-to)720-728
Number of pages9
JournalDigestive Diseases and Sciences
Volume49
Issue number5
DOIs
StatePublished - May 1 2004
Externally publishedYes

    Fingerprint

Keywords

  • electrical stimulation
  • emetic symptoms
  • intestinal motility
  • slow waves
  • vasopressin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this