Effects of interleukin-2 on renal function in patients receiving immunotherapy for advanced cancer

A. Belldegrun, D. E. Webb, H. A. Austin, S. M. Steinberg, D. E. White, W. M. Linehan, S. A. Rosenberg

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Abstract

Adoptive transfer of autologous lymphokine-activated killer cells in conjunction with recombinant interleukin-2 in patients with advanced cancer has produced significant regression of metastatic disease in selected patients. We analyzed the effects of interleukin-2 regimens on renal function in 99 consecutive patients. Interleukin-2 therapy with or without lymphokine-activated killer cells was associated with varying degrees of hypotension, fluid retention, azotemia, oliguria, and low fractional sodium excretion. After the patients completed the interleukin-2 regimens, their renal function improved promptly. Renal function values returned to baseline levels within 7 days in 62% of patients, within 14 days in 84%, and within 30 days in 95%. Pretherapy serum creatinine values above 1.4 mg/dL predicted the severity of azotemia and prolonged duration of renal functional recovery. Interleukin-2 therapeutic regimens induce prerenal azotemia. Careful selection of patients and early detection of adverse physiologic changes may alleviate the side effects of interleukin-2 therapy.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalAnnals of Internal Medicine
Volume106
Issue number6
Publication statusPublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Belldegrun, A., Webb, D. E., Austin, H. A., Steinberg, S. M., White, D. E., Linehan, W. M., & Rosenberg, S. A. (1987). Effects of interleukin-2 on renal function in patients receiving immunotherapy for advanced cancer. Annals of Internal Medicine, 106(6), 817-822.