Effects of interleukin-13 on antifungal activity of human monocytes against Candida albicans

Helen Katsifa, Sevasti Tsaparidou, Evdoxia Diza, Cristina Gil-Lamaignere, Thomas J. Walsh, Emmanuel Roilides

Research output: Contribution to journalArticle

Abstract

We investigated the effects of human interleukin-13 (IL-13) on human monocytes' (MNC) activities against Candida albicans, an important human pathogen. Increased phagocytosis of blastoconidia was observed after incubation with 50 U ml-1 of IL-13 for 4 h or 48 h in the presence or absence of serum. The latter effect was inhibited by anti-IL-13 monoclonal antibody or mannose. Incubation of MNC with 50 U ml-1 of IL-13 for 2 h significantly enhanced superoxide anion production in response to phorbol myristate acetate. IL-13 did not, however, alter the damage caused by MNC to hyphae, whereas it suppressed killing of blastoconidia. IL-13 has variable effects on MNC activities and may play an important immunoregulatory role against C. albicans.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume31
Issue number3
DOIs
StatePublished - Dec 5 2001

Keywords

  • Candida albicans
  • Interleukin-13
  • Monocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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