Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells

Aspasia Katragkou, Maria Simitsopoulou, Athanasios Chatzimoschou, Elpiniki Georgiadou, Thomas J. Walsh, Emmanuel Roilides

Research output: Contribution to journalArticlepeer-review

Abstract

Candida albicans is a leading cause of biofilm-related infections. As Candida biofilms are recalcitrant to host defenses, we sought to determine the effects of interferon-γ and granulocyte colony-stimulating factor, two pro-inflammatory cytokines, on the antifungal activities of human polymorphonuclear neutrophils (PMNs) against C. albicans biofilms, using an in vitro biofilm model. Priming of PMNs by these cytokines augmented fungal damage of planktonic cells; however, priming of PMNs did not have the same effect against Candida biofilms. Biofilm phenotype appears to play an important role in protecting C. albicans from the innate immune system.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalCytokine
Volume55
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Biofilm
  • Candida albicans
  • G-CSF
  • IFN-γ
  • Neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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