1. 1. An apparatus has been described for inducing systemic oxygen want in patients, without rebreathing. 2. 2. Observations were made on 37 patients with cardiac disease and on 11 with normal hearts. A level of oxygen saturation was reached ranging from 67 to 83 per cent, as determined in samples of arterial blood. 3. 3. There was no constant relationship between the occurrence of cardiac pain and changes in heart rate, respiratory rate, blood pressure, venous pressure, circulation time and the degree of arterial unsaturation. 4. 4. Pain occurred inconstantly in repeated tests, except in two patients with aortic stenosis and in one with advanced coronary lesions. In the two patients with aortic stenosis there was no compensatory shortening of the circulation time during the anoxemic period. 5. 5. Untoward effects were observed in two patients with healed infarcts of the heart. Both recovered promptly. The bearing of these experiences on the danger of aeroplane flights for persons with disease of the coronary arteries was discussed. 6. 6. Oxygen want is an important, and apparently the determining factor in the causation of cardiac pain. It is most effective when the coronary blood flow is reduced. Ischemia and anoxemia complement each other as pain-inducing agents in the heart. Other variable circumstances are also concerned. 7. 7. The induction of systemic oxygen want may prove to be useful as a test for coronary insufficiency; it is not recommended for general use at this time.
|Original language||English (US)|
|Number of pages||14|
|Journal||American Heart Journal|
|State||Published - Feb 1938|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine