Effects of indomethacin on renal inner medullary plasma flow

Kim Solez, Jennifer A. Fox, Marilyn Miller, Robert H. Heptinstall

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalProstaglandins
Volume7
Issue number2
DOIs
StatePublished - Jul 25 1974

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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