Effects of indomethacin on renal inner medullary plasma flow

Kim Solez, Jennifer A. Fox, Marilyn Miller, Robert H. Heptinstall

Research output: Contribution to journalArticle

Abstract

The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalProstaglandins
Volume7
Issue number2
DOIs
StatePublished - Jul 25 1974

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Plasma flow
Indomethacin
Prostaglandins
Kidney
Prostaglandins A
Renal Plasma Flow
Prostaglandin Antagonists
Renal Circulation
Hemodynamics
Prostaglandins E
Rats
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Solez, K., Fox, J. A., Miller, M., & Heptinstall, R. H. (1974). Effects of indomethacin on renal inner medullary plasma flow. Prostaglandins, 7(2), 91-98. https://doi.org/10.1016/0090-6980(74)90126-9

Effects of indomethacin on renal inner medullary plasma flow. / Solez, Kim; Fox, Jennifer A.; Miller, Marilyn; Heptinstall, Robert H.

In: Prostaglandins, Vol. 7, No. 2, 25.07.1974, p. 91-98.

Research output: Contribution to journalArticle

Solez, K, Fox, JA, Miller, M & Heptinstall, RH 1974, 'Effects of indomethacin on renal inner medullary plasma flow', Prostaglandins, vol. 7, no. 2, pp. 91-98. https://doi.org/10.1016/0090-6980(74)90126-9
Solez, Kim ; Fox, Jennifer A. ; Miller, Marilyn ; Heptinstall, Robert H. / Effects of indomethacin on renal inner medullary plasma flow. In: Prostaglandins. 1974 ; Vol. 7, No. 2. pp. 91-98.
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