Effects of indomethacin and prostaglandin F on ovulation and ovarian contractility in the rabbit

Augusto Diaz-Infante, Karen H. Wright, Edward E. Wallach

Research output: Contribution to journalArticlepeer-review


The present investigation was carried out to determine whether inhibition of ovulation in the rabbit by administration of indomethacin can be correlated with any change in ovarian contractility at ovulation time and can be reversed by administration of prostaglandins. Indomethacin was adminstered intra-muscularly using three different schedules in a dose of 5 mg/kg. A reduced number of ruptured follicles following HCG was noted in all groups treated with indomethacin. Infusion of PGF into the aorta (1 μg/kg/min.) could reverse this effect. Less pronounced ovarian contractility was observed after indomethacin treatment, but infusion of PGF immediately enhanced contractility in ovaries from indomethacin treated rabbits. The inhibition of ovulation in the rabbit associated with indomethacin adminstration may be related to suppression of ovarian contractions. These data also suggest that prostaglandins may play a significant role in the mechanism of ovulation through an influence on ovarian contractility.

Original languageEnglish (US)
Pages (from-to)567-581
Number of pages15
Issue number6
StatePublished - Mar 25 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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