Effects of hypoxia on tumor metabolism

Jung Whan Kim; Ping Gao; Chi V. Dang

doi:10.1007/s10555-007-9060-4

Effects of hypoxia on tumor metabolism

Jung Whan Kim, Ping Gao, Chi V. Dang

School of Medicine

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.

Original language	English (US)
Pages (from-to)	291-298
Number of pages	8
Journal	Cancer and Metastasis Reviews
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s10555-007-9060-4
State	Published - Jun 1 2007

Keywords

Hypoxia
Hypoxia-inducible factor
Metabolism
Tumor
Tumor bioenergetic

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10555-007-9060-4

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AU - Gao, Ping

AU - Dang, Chi V.

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N2 - Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.

AB - Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.

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KW - Hypoxia-inducible factor

KW - Metabolism

KW - Tumor

KW - Tumor bioenergetic

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Effects of hypoxia on tumor metabolism

Abstract

Keywords

ASJC Scopus subject areas

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