Effects of hypoxia on tumor metabolism

Jung Whan Kim, Ping Gao, Chi V. Dang

Research output: Contribution to journalReview article

Abstract

Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalCancer and Metastasis Reviews
Volume26
Issue number2
DOIs
StatePublished - Jun 1 2007

    Fingerprint

Keywords

  • Hypoxia
  • Hypoxia-inducible factor
  • Metabolism
  • Tumor
  • Tumor bioenergetic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this