Effects of Hypercapnia on Renal Nerve Activity

Machiko Shirahata, Takashi Nishino, Toshihide Yonezawa, Yoshiyuki Honda, Kazuto Itoh

Research output: Contribution to journalArticle

Abstract

We investigated the response of renal nerve activity (RNA) to hypercapnia and assessed the contribution of the peripheral chemoreceptors to the response of RNA in anesthetized and artificially ventilated cats. RNA and arterial pressure were recorded at four levels of [formula omitted] with hyperoxia in intact and in peripheral chemoreceptor denervated cats. In intact cats, RNA increased progressively with increasing [formula omitted], while no consistent change in arterial pressure was observed. In peripheral chemoreceptor denervated cats, the response of RNA to increasing [formula omitted] was totally abolished. These results suggest that the peripheral chemoreceptors play an important role in increasing RNA during hypercapnia.

Original languageEnglish (US)
Pages (from-to)391-399
Number of pages9
JournalThe Japanese Journal of Physiology
Volume35
Issue number3
DOIs
StatePublished - Jan 1 1985

Keywords

  • hypercapnia
  • peripheral chemoreceptors
  • renal nerve activity

ASJC Scopus subject areas

  • Physiology

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    Shirahata, M., Nishino, T., Yonezawa, T., Honda, Y., & Itoh, K. (1985). Effects of Hypercapnia on Renal Nerve Activity. The Japanese Journal of Physiology, 35(3), 391-399. https://doi.org/10.2170/jjphysiol.35.391