Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul; Solomon H. Snyder; Khosrow Kashfi

doi:10.1016/j.redox.2020.101772

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul, Solomon H. Snyder, Khosrow Kashfi

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Hydrogen sulfide (H₂S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H₂S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H₂S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H₂S in mitochondrial function and its effects on cellular physiology.

Original language	English (US)
Article number	101772
Journal	Redox Biology
Volume	38
DOIs	https://doi.org/10.1016/j.redox.2020.101772
State	Published - Jan 2021

Keywords

Bioenergetics
Cell signaling
Hydrogen sulfide
Mitochondria
Sulfhydration/persulfidation
Sulfide oxidation

ASJC Scopus subject areas

Organic Chemistry

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10.1016/j.redox.2020.101772

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title = "Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics",

abstract = "Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.",

keywords = "Bioenergetics, Cell signaling, Hydrogen sulfide, Mitochondria, Sulfhydration/persulfidation, Sulfide oxidation",

author = "Paul, {Bindu D.} and Snyder, {Solomon H.} and Khosrow Kashfi",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = jan,

doi = "10.1016/j.redox.2020.101772",

language = "English (US)",

volume = "38",

journal = "Redox Biology",

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TY - JOUR

T1 - Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

AU - Paul, Bindu D.

AU - Snyder, Solomon H.

AU - Kashfi, Khosrow

PY - 2021/1

Y1 - 2021/1

N2 - Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.

AB - Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.

KW - Bioenergetics

KW - Cell signaling

KW - Hydrogen sulfide

KW - Mitochondria

KW - Sulfhydration/persulfidation

KW - Sulfide oxidation

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DO - 10.1016/j.redox.2020.101772

M3 - Short survey

C2 - 33137711

AN - SCOPUS:85094184413

SN - 2213-2317

VL - 38

JO - Redox Biology

JF - Redox Biology

M1 - 101772

ER -

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Abstract

Keywords

ASJC Scopus subject areas

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