Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Research output: Contribution to journalShort surveypeer-review

Abstract

Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.

Original languageEnglish (US)
Article number101772
JournalRedox Biology
Volume38
DOIs
StatePublished - Jan 2021

Keywords

  • Bioenergetics
  • Cell signaling
  • Hydrogen sulfide
  • Mitochondria
  • Sulfhydration/persulfidation
  • Sulfide oxidation

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

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