Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research and Development and Research Training in Human Reproduction

M. Tankeyoon, N. Dusitsin, Sopon Chalapati, Suporn Koetsawang, S. Saibiang, M. Sas, J. J. Gellen, O. Ayeni, Ronald H Gray, A. Pinol, L. Zegers

Research output: Contribution to journalArticle

Abstract

WHO conducted a three-centre study in Hungary and Thailand to evaluate the effects of hormonal contraception on lactation and infant growth. Women choosing oral contraceptives were randomly assigned to a combined oral contraceptive containing 30ug ethinyl estradiol and 150ug levonorgestrel (N=86) or a progestin-only preparation containing 75ug dl-norgestrel (N=85). Identical packaging and treatment schedules allowed double-blind observation. One-hundred-and-eleven women using no contraception or non-hormonal methods acted as controls. In the two Thai centres 59 women using depot-medroxyprogesterone acetate formed an additional comparison group. All subjects were healthy women with normal deliveries, whose infants had normal birth weights and satisfactory growth in the neonatal period. Breast milk volume was determined by pump expression using standardized procedures. Information was obtained on nursing frequency and supplementation, infant growth and morbidity. Pretreatment observations at 6 weeks post-partum were used as a baseline, and subjects were followed-up at 9, 12, 16, 20 and 24 weeks post-partum. Women using combined oral contraceptives had a decline in milk volume within 6 weeks of initiating treatment, whereas no significant decrease was observed in the other treatment groups. After 18 weeks of treatment, combined oral contraceptive users experienced a 41.9% decline in milk volume, compared to 12.0% with progestin-only minipills and 6.1% in the non-hormonal controls. The prevalence of complementary feeding and withdrawals due to inadequate milk supply were comparable in the four treatment groups. However, data were not available on the daily amounts of complementary feeds. There were no significant differences in growth of infants between treatment groups. Thus, women may have compensated for declines in milk volume by more supplementary feeding or by more prolonged and intense suckling episodes. We conclude that 30 ug estrogen-containing combined oral contraceptives impair milk secretion, but in the selected healthy group of mothers and children studied with the prevailing level of supplementary feeding, this did not adversely affect infant growth.

Original languageEnglish (US)
Pages (from-to)505-522
Number of pages18
JournalContraception
Volume30
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

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Contraceptive Agents
Contraceptives, Oral, Combined
Reproduction
Milk
Infant Nutritional Physiological Phenomena
Growth
Research
Progestins
Contraception
Therapeutics
Norgestrel
Medroxyprogesterone Acetate
Hungary
Product Packaging
Human Milk
Thailand
Oral Contraceptives
Lactation
Birth Weight
Appointments and Schedules

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research and Development and Research Training in Human Reproduction. / Tankeyoon, M.; Dusitsin, N.; Chalapati, Sopon; Koetsawang, Suporn; Saibiang, S.; Sas, M.; Gellen, J. J.; Ayeni, O.; Gray, Ronald H; Pinol, A.; Zegers, L.

In: Contraception, Vol. 30, No. 6, 1984, p. 505-522.

Research output: Contribution to journalArticle

Tankeyoon, M, Dusitsin, N, Chalapati, S, Koetsawang, S, Saibiang, S, Sas, M, Gellen, JJ, Ayeni, O, Gray, RH, Pinol, A & Zegers, L 1984, 'Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research and Development and Research Training in Human Reproduction', Contraception, vol. 30, no. 6, pp. 505-522. https://doi.org/10.1016/0010-7824(84)90001-5
Tankeyoon, M. ; Dusitsin, N. ; Chalapati, Sopon ; Koetsawang, Suporn ; Saibiang, S. ; Sas, M. ; Gellen, J. J. ; Ayeni, O. ; Gray, Ronald H ; Pinol, A. ; Zegers, L. / Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research and Development and Research Training in Human Reproduction. In: Contraception. 1984 ; Vol. 30, No. 6. pp. 505-522.
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