Effects of hexachlorocyclohexane isomers on the mitogenic response of bovine lymphocytes

Thomas W. Kensler, Gerald C. Mueller

Research output: Contribution to journalArticlepeer-review

Abstract

The α-, β-, γ- and δ-isomers of hexachlorocyclohexane (HCH) were evaluated as modifiers of the mitogenic response in cultured bovine lymphocytes. None of the four isomers were mitogenic alone; however, the concurrent administration of αHCH and phytohemagglutinin-P (PHA) stimulated DNA synthesis in lymphocyte cultures 2.2-fold over that obtained with PHA alone. βHCH was inactive in the test system whereas both γ- and δHCH severely inhibited the PHA response. Treatment of lymphocytes with the microsomal enzyme inhibitor SKF-525A blocked the co-mitogenic activity of αHCH without affecting the basal PHA response. The role of hexachlorocyclohexane-sensitive metabolic systems in the regulation of mitogenesis in lymphocytes is discussed.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalBiochemical Pharmacology
Volume27
Issue number5
DOIs
StatePublished - Mar 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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