Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects

Elsa J. Bartlett, Jonathan D. Brodie, Philip Simkowitz, Stephen L. Dewey, Henry Rusinek, Alfred P. Wolf, Joanna S. Fowler, Nora D. Volkow, Gwenn Smith, Adam Wolkin, Robert Cancro

Research output: Contribution to journalArticle

Abstract

Objective: Positron emission tomography and the fluorodeoxyglucose (FDG) method were used to determine the brain's metabolic response to neuroleptic challenge in a normal, disease-free state. Method: FDG measurements were obtained before and 12 hours after administration of 5 mg of haloperidol to 12 young normal men. These values were compared with test-retest FDG measures obtained from nine normal male control subjects who received no drug intervention. Results: After haloperidol administration, the haloperidol subjects showed significantly lower glucose utilization in the neocortex, limbic cortex, thalamus, and caudate nucleus but not in the putamen or cerebellum. After adjustment for global effects, significant reductions were still evident in the frontal, occipital, and anterior cingulate cortex, whereas the putamen and cerebellum showed significant increases. Conclusions: This study, measuring the brain's metabolic response to acute receptor blockade, is a first step in the development of an assay of CNS pharmacological activity. By determining the response to neuroleptic challenge in a normal state, the study establishes a comparison group for determining response to challenge in various psychiatric conditions.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
JournalAmerican Journal of Psychiatry
Volume151
Issue number5
StatePublished - May 1994
Externally publishedYes

Fingerprint

Haloperidol
Putamen
Glucose
Cerebellum
Antipsychotic Agents
Caudate Nucleus
Neocortex
Gyrus Cinguli
Brain
Thalamus
Positron-Emission Tomography
Psychiatry
Pharmacology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bartlett, E. J., Brodie, J. D., Simkowitz, P., Dewey, S. L., Rusinek, H., Wolf, A. P., ... Cancro, R. (1994). Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. American Journal of Psychiatry, 151(5), 681-686.

Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. / Bartlett, Elsa J.; Brodie, Jonathan D.; Simkowitz, Philip; Dewey, Stephen L.; Rusinek, Henry; Wolf, Alfred P.; Fowler, Joanna S.; Volkow, Nora D.; Smith, Gwenn; Wolkin, Adam; Cancro, Robert.

In: American Journal of Psychiatry, Vol. 151, No. 5, 05.1994, p. 681-686.

Research output: Contribution to journalArticle

Bartlett, EJ, Brodie, JD, Simkowitz, P, Dewey, SL, Rusinek, H, Wolf, AP, Fowler, JS, Volkow, ND, Smith, G, Wolkin, A & Cancro, R 1994, 'Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects', American Journal of Psychiatry, vol. 151, no. 5, pp. 681-686.
Bartlett EJ, Brodie JD, Simkowitz P, Dewey SL, Rusinek H, Wolf AP et al. Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. American Journal of Psychiatry. 1994 May;151(5):681-686.
Bartlett, Elsa J. ; Brodie, Jonathan D. ; Simkowitz, Philip ; Dewey, Stephen L. ; Rusinek, Henry ; Wolf, Alfred P. ; Fowler, Joanna S. ; Volkow, Nora D. ; Smith, Gwenn ; Wolkin, Adam ; Cancro, Robert. / Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. In: American Journal of Psychiatry. 1994 ; Vol. 151, No. 5. pp. 681-686.
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