Effects of gastric electrical field stimulation with long pulses on gastric emptying in dogs

H. Ouyang, J. Yin, H. Zhu, X. Xu, Jiande D.Z. Chen

Research output: Contribution to journalArticle

Abstract

The aim was to investigate the effects of electrical field stimulation (EFS) with long and short pulses on gastric emptying, gastric contractility and vagal activity in dogs. Sixteen dogs were equipped with a duodenal cannula, electrodes and strain gauges (10 dogs) in the stomach. Each dog was fed with Ensure and gastric effluent was collected from the cannula. Electrical stimulation was applied via two electrodes (about 12 cm apart, one in the corpus and the other in the antrum) with long pulses (a frequency of 6 cycles min-1, pulse amplitude of 6 mA and width of 100 ms) in 10 dogs and with short pulses (frequency of 30 Hz and pulse width of 300 μs) in six dogs. The electrocardiogram was also recorded and heart rate variability was derived to assess the vagal activity. It was found that: (i) EFS with long pulses did not alter gastric emptying during stimulation but increased gastric emptying during the 45 min immediately after stimulation; (ii) EFS with long pulses increased gastric contractility in both proximal and distal antrum during and after the stimulation; (iii) EFS with long pulses resulted in an increase in vagal tone during the 45 min immediately after stimulation. However, there is no difference during the 45 min period of stimulation; (iv) EFS with short pulses had no effect on gastric emptying. We concluded that long pulse gastric electrical field stimulation with one electrode in the corpus and the other electrode in the antrum has postponed effects on gastric emptying of liquid, gastric contractility and vagal activity.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalNeurogastroenterology and Motility
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Electrical field stimulation
  • Gastric contractile activity
  • Gastric emptying
  • Gastric myoelectrical activity
  • Heart rate variability

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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