TY - GEN
T1 - Effects of gap junction conductance on oscillation properties of coupled sino-atrial node cells
AU - Cai, D.
AU - Winslow, R. L.
AU - Noble, D.
N1 - Publisher Copyright:
© 1992 IEEE.
PY - 1992
Y1 - 1992
N2 - Dynamics of electrically coupled model sino-atrial (SA) node cells were studied as a function of coupling conductance. Simulation results demonstrate at least four distinct regimes of behavior as coupling conductance is varied: (a) independent oscillation; (b) quasi-periodic oscillation; (c) frequency, but not waveform entrainment; and (d) frequency and waveform entrainment. The conductance of single cardiac myocyte gap junction channels is about 50 pS. These simulations therefore show that as few as four to five gap junction channels between each cell are required for frequency entrainment. Analyses of large-scale SA node network models implemented on the Connection Machine CM-2 supercomputer indicate that frequency entrainment of large networks is also supported by a small number of gap junction channels between neighboring cells.
AB - Dynamics of electrically coupled model sino-atrial (SA) node cells were studied as a function of coupling conductance. Simulation results demonstrate at least four distinct regimes of behavior as coupling conductance is varied: (a) independent oscillation; (b) quasi-periodic oscillation; (c) frequency, but not waveform entrainment; and (d) frequency and waveform entrainment. The conductance of single cardiac myocyte gap junction channels is about 50 pS. These simulations therefore show that as few as four to five gap junction channels between each cell are required for frequency entrainment. Analyses of large-scale SA node network models implemented on the Connection Machine CM-2 supercomputer indicate that frequency entrainment of large networks is also supported by a small number of gap junction channels between neighboring cells.
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U2 - 10.1109/CIC.1992.269542
DO - 10.1109/CIC.1992.269542
M3 - Conference contribution
AN - SCOPUS:84927903539
T3 - Proceedings - Computers in Cardiology, CIC 1992
SP - 579
EP - 582
BT - Proceedings - Computers in Cardiology, CIC 1992
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 1992 IEEE Conference on Computers in Cardiology, CIC 1992
Y2 - 11 October 1992 through 14 October 1992
ER -