Effects of gap junction conductance on oscillation properties of coupled sino-atrial node cells

D. Cai, R. L. Winslow, D. Noble

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamics of electrically coupled model sino-atrial (SA) node cells were studied as a function of coupling conductance. Simulation results demonstrate at least four distinct regimes of behavior as coupling conductance is varied: (a) independent oscillation; (b) quasi-periodic oscillation; (c) frequency, but not waveform entrainment; and (d) frequency and waveform entrainment. The conductance of single cardiac myocyte gap junction channels is about 50 pS. These simulations therefore show that as few as four to five gap junction channels between each cell are required for frequency entrainment. Analyses of large-scale SA node network models implemented on the Connection Machine CM-2 supercomputer indicate that frequency entrainment of large networks is also supported by a small number of gap junction channels between neighboring cells.

Original languageEnglish (US)
Title of host publicationProceedings - Computers in Cardiology, CIC 1992
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages579-582
Number of pages4
ISBN (Electronic)0818635525, 9780818635526
DOIs
StatePublished - 1992
Event1992 IEEE Conference on Computers in Cardiology, CIC 1992 - Durham, United States
Duration: Oct 11 1992Oct 14 1992

Publication series

NameProceedings - Computers in Cardiology, CIC 1992

Conference

Conference1992 IEEE Conference on Computers in Cardiology, CIC 1992
Country/TerritoryUnited States
CityDurham
Period10/11/9210/14/92

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering

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