Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients

Rudolf Hoehn-Saric, Godfrey D. Pearlson, Gordon J. Harris, Steven R. Machlin, Edwaldo E. Camargo

Research output: Contribution to journalArticlepeer-review

Abstract

Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.

Original languageEnglish (US)
Pages (from-to)1243-1245
Number of pages3
JournalAmerican Journal of Psychiatry
Volume148
Issue number9
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Psychiatry and Mental health

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