Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs

M. Yaster, Raymond C Koehler, R. J. Traystman

Research output: Contribution to journalArticle

Abstract

The effects of fentanyl on cardiovascular function, regional distribution of cardiac output, and the dose required for producing anesthesia were studied in ten previously catheterized, newborn lambs. In addition, the effects of fentanyl on cerebral blood flow and oxygen utilization were examined. Fentanyl in cumulative doses as high as 4.4 mg/kg (average plasma levels of 646 ± 95 ng/ml, maximum plasma level of 862 ng/ml) did not reliably produce anesthesia as assessed by tail and foot clamping, although it did cause profound respiratory depression. With normocapnia maintained by mechanical ventilation, fentanyl did not alter cerebral oxygen delivery or consumption, and the two remained coupled. Fentanyl did not affect cardiac output, heart rate, or mean arterial blood pressure at the highest dose level, nor did it reduce blood flow to specific organ beds, other than the kidney. Thus, the hemodynamic stability seen with fentanyl in the lamb does not occur at the expense of reduced blood flow to organs, such as the gastrointestinal tract or brain, that are particularly vulnerable in the neonate.

Original languageEnglish (US)
Pages (from-to)524-530
Number of pages7
JournalAnesthesiology
Volume66
Issue number4
StatePublished - 1987

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Fentanyl
Hemodynamics
Cardiac Output
Cerebrovascular Circulation
Arterial Pressure
Anesthesia
Oxygen
Artificial Respiration
Constriction
Respiratory Insufficiency
Gastrointestinal Tract
Foot
Heart Rate
Kidney
Brain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs. / Yaster, M.; Koehler, Raymond C; Traystman, R. J.

In: Anesthesiology, Vol. 66, No. 4, 1987, p. 524-530.

Research output: Contribution to journalArticle

Yaster, M. ; Koehler, Raymond C ; Traystman, R. J. / Effects of fentanyl on peripheral and cerebral hemodynamics in neonatal lambs. In: Anesthesiology. 1987 ; Vol. 66, No. 4. pp. 524-530.
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