TY - JOUR
T1 - Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease
AU - Brendle, David C.
AU - Joseph, Lyndon J.O.
AU - Corretti, Mary C.
AU - Gardner, Andrew W.
AU - Katzel, Leslie I.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelial function, which is a measure of vascular health, is impaired in patients with PAD. We examined the effects of 6 months of aerobic exercise rehabilitation on brachial artery endothelial function, assessed using high-frequency ultrasonography, and calf blood flow in 19 older PAD patients (age 69 ± 1 years, mean ± SEM) with intermittent claudication (ankle to brachial artery index of 0.73 ± 0.04). After exercise, the time to onset of claudication pain increased by 94%, from 271 ± 49 to 525 ± 80 seconds (p <0.01), and the time to maximal claudication pain increased by 43%, from 623 ± 77 to 889 ± 75 seconds (p <0.05). Exercise rehabilitation increased the flow-mediated brachial arterial diameter by 61%, from 0.18 ± 0.03 to 0.29 ± 0.04 mm (p <0.005), as well as the relative change in brachial arterial diameter from the resting state by 60%, from 4.81 ± 0.82% to 7.97 ± 1.03% (p <0.005). Maximal calf blood flow (14.2 ± 1.0 vs 19.2 ± 2.0 ml/100 ml/min; p = 0.04), and postocclusive reactive hyperemic blood flow (9.8 ± 0.8 vs 11.3 ± 0.7 ml/100 ml/min; p = 0.1) increased 35% and 15%, respectively. In conclusion, exercise rehabilitation improved ambulatory function, endothelial-dependent dilation, and calf blood flow in older PAD patients with intermittent claudication.
AB - Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelial function, which is a measure of vascular health, is impaired in patients with PAD. We examined the effects of 6 months of aerobic exercise rehabilitation on brachial artery endothelial function, assessed using high-frequency ultrasonography, and calf blood flow in 19 older PAD patients (age 69 ± 1 years, mean ± SEM) with intermittent claudication (ankle to brachial artery index of 0.73 ± 0.04). After exercise, the time to onset of claudication pain increased by 94%, from 271 ± 49 to 525 ± 80 seconds (p <0.01), and the time to maximal claudication pain increased by 43%, from 623 ± 77 to 889 ± 75 seconds (p <0.05). Exercise rehabilitation increased the flow-mediated brachial arterial diameter by 61%, from 0.18 ± 0.03 to 0.29 ± 0.04 mm (p <0.005), as well as the relative change in brachial arterial diameter from the resting state by 60%, from 4.81 ± 0.82% to 7.97 ± 1.03% (p <0.005). Maximal calf blood flow (14.2 ± 1.0 vs 19.2 ± 2.0 ml/100 ml/min; p = 0.04), and postocclusive reactive hyperemic blood flow (9.8 ± 0.8 vs 11.3 ± 0.7 ml/100 ml/min; p = 0.1) increased 35% and 15%, respectively. In conclusion, exercise rehabilitation improved ambulatory function, endothelial-dependent dilation, and calf blood flow in older PAD patients with intermittent claudication.
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U2 - 10.1016/S0002-9149(00)01367-9
DO - 10.1016/S0002-9149(00)01367-9
M3 - Article
C2 - 11165969
AN - SCOPUS:0035253105
SN - 0002-9149
VL - 87
SP - 324
EP - 329
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -