Background: Preclinical studies demonstrate that 17β-estradiol (E2) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. Methods: We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [18F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E2, 0.1 mg/d, and following 2 to 6 weeks of E2 plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. Results: There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2% ± 2.6% following combined E2 and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. Conclusions: 5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E2 + P administration. (C) 2000 Society of Biological Psychiatry.
ASJC Scopus subject areas
- Biological Psychiatry