Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: A PET study

Eydie L. Moses; Wayne C. Drevets; Gwenn Smith; Chester A. Mathis; Brinda N. Kalro; Meryl A. Butters; Mark P. Leondires; Phil J. Greer; Brian Lopresti; Tammy L. Loucks; Sarah L. Berga

doi:10.1016/S0006-3223(00)00967-7

Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: A PET study

Eydie L. Moses, Wayne C. Drevets, Gwenn Smith, Chester A. Mathis, Brinda N. Kalro, Meryl A. Butters, Mark P. Leondires, Phil J. Greer, Brian Lopresti, Tammy L. Loucks, Sarah L. Berga

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Background: Preclinical studies demonstrate that 17β-estradiol (E₂) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. Methods: We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [¹⁸F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E₂, 0.1 mg/d, and following 2 to 6 weeks of E₂ plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. Results: There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2% ± 2.6% following combined E₂ and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. Conclusions: 5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E₂ + P administration. (C) 2000 Society of Biological Psychiatry.

Original language	English (US)
Pages (from-to)	854-860
Number of pages	7
Journal	Biological psychiatry
Volume	48
Issue number	8
DOIs	https://doi.org/10.1016/S0006-3223(00)00967-7
State	Published - Oct 15 2000
Externally published	Yes

Keywords

5-HT(2A)
Behavior
Estradiol
Neurotrophin
PET
Progesterone

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/S0006-3223(00)00967-7

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@article{e45e7bd705a74e76a05809db395dff36,

title = "Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: A PET study",

abstract = "Background: Preclinical studies demonstrate that 17β-estradiol (E2) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. Methods: We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [18F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E2, 0.1 mg/d, and following 2 to 6 weeks of E2 plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. Results: There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2% ± 2.6% following combined E2 and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. Conclusions: 5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E2 + P administration. (C) 2000 Society of Biological Psychiatry.",

keywords = "5-HT(2A), Behavior, Estradiol, Neurotrophin, PET, Progesterone",

author = "Moses, {Eydie L.} and Drevets, {Wayne C.} and Gwenn Smith and Mathis, {Chester A.} and Kalro, {Brinda N.} and Butters, {Meryl A.} and Leondires, {Mark P.} and Greer, {Phil J.} and Brian Lopresti and Loucks, {Tammy L.} and Berga, {Sarah L.}",

note = "Funding Information: This study was supported by National Institute of Health Grant Nos. MH16804, MH01713, MH/HD50748, MH01621, MH49936, MH57078, and MH52247 (Intervention Research Center for Late-Life Mood Disorders); National Center for Research Resources Grant No. RR-00056 to the University of Pittsburgh School of Medicine General Clinical Research Center; and the Functional Imaging Research Program of the Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. ",

year = "2000",

month = oct,

day = "15",

doi = "10.1016/S0006-3223(00)00967-7",

language = "English (US)",

volume = "48",

pages = "854--860",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "8",

}

TY - JOUR

T1 - Effects of estradiol and progesterone administration on human serotonin 2A receptor binding

T2 - A PET study

AU - Moses, Eydie L.

AU - Drevets, Wayne C.

AU - Smith, Gwenn

AU - Mathis, Chester A.

AU - Kalro, Brinda N.

AU - Butters, Meryl A.

AU - Leondires, Mark P.

AU - Greer, Phil J.

AU - Lopresti, Brian

AU - Loucks, Tammy L.

AU - Berga, Sarah L.

N1 - Funding Information: This study was supported by National Institute of Health Grant Nos. MH16804, MH01713, MH/HD50748, MH01621, MH49936, MH57078, and MH52247 (Intervention Research Center for Late-Life Mood Disorders); National Center for Research Resources Grant No. RR-00056 to the University of Pittsburgh School of Medicine General Clinical Research Center; and the Functional Imaging Research Program of the Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

PY - 2000/10/15

Y1 - 2000/10/15

N2 - Background: Preclinical studies demonstrate that 17β-estradiol (E2) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. Methods: We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [18F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E2, 0.1 mg/d, and following 2 to 6 weeks of E2 plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. Results: There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2% ± 2.6% following combined E2 and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. Conclusions: 5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E2 + P administration. (C) 2000 Society of Biological Psychiatry.

AB - Background: Preclinical studies demonstrate that 17β-estradiol (E2) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. Methods: We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [18F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E2, 0.1 mg/d, and following 2 to 6 weeks of E2 plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. Results: There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2% ± 2.6% following combined E2 and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. Conclusions: 5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E2 + P administration. (C) 2000 Society of Biological Psychiatry.

KW - 5-HT(2A)

KW - Behavior

KW - Estradiol

KW - Neurotrophin

KW - PET

KW - Progesterone

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UR - http://www.scopus.com/inward/citedby.url?scp=0034667339&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(00)00967-7

DO - 10.1016/S0006-3223(00)00967-7

M3 - Article

C2 - 11063980

AN - SCOPUS:0034667339

SN - 0006-3223

VL - 48

SP - 854

EP - 860

JO - Biological psychiatry

JF - Biological psychiatry

IS - 8

ER -

Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: A PET study

Abstract

Keywords

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