Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract

Markad V. Kamath, Andrew May, Stephan Hollerbach, Debbie Fitzpatrick, Robert Bulat, Absar Bajwa, Gervais Tougas, Ernest L. Fallen, Glen Shine, Adrian R. Upton

Research output: Contribution to journalArticle

Abstract

We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and noncardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 361 μV in controls, p < 0.04), while peak latenceis were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalCritical Reviews in Biomedical Engineering
Volume28
Issue number1-2
Publication statusPublished - Sep 26 2000
Externally publishedYes

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Keywords

  • Autonomic nervous system
  • Diabetes
  • Evoked potentials
  • Heart rate variability
  • Non-cardiac chest pain

ASJC Scopus subject areas

  • Medicine(all)
  • Biomedical Engineering

Cite this

Kamath, M. V., May, A., Hollerbach, S., Fitzpatrick, D., Bulat, R., Bajwa, A., ... Upton, A. R. (2000). Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract. Critical Reviews in Biomedical Engineering, 28(1-2), 87-93.