Effects of ergot drugs on serotonergic function: Behavior and neurochemistry

Ellen K. Silbergeld, Robert E. Hruska

Research output: Contribution to journalArticle

Abstract

Several new ergot drugs were tested for behavioral and neurochemical effects related to serotonergic function. Lergotrile and bromocriptine potentiated the so-called "5-HT syndrome", a set of behaviours associated with increased serotonergic neurotransmission consequent to monoamine oxidase inhibition and tryptophan loading. Metergoline antagonized this behavior. In studies of receptor binding using 3H-5-HT or 3H-LSD, metergoline was the most potent at displacing specifice ligand binding. Since the ergots also affect of dopaminergic function, these results are discussed for their information on both dopaminergic and serotonergic actions of these drugs and their implications for clinical use of ergots.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalEuropean Journal of Pharmacology
Volume58
Issue number1
DOIs
StatePublished - Sep 1 1979
Externally publishedYes

Keywords

  • Dopamine
  • Ergot drugs
  • Parkinsonism
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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