Effects of enamel matrix genes on dental caries are moderated by fluoride exposures

John R. Shaffer, Jenna C. Carlson, Brooklyn O C Stanley, Eleanor Feingold, Margaret Cooper, Michael M. Vanyukov, Brion Maher, Rebecca L. Slayton, Marcia C. Willing, Steven E. Reis, Daniel W. McNeil, Richard J. Crout, Robert J. Weyant, Steven M. Levy, Alexandre R. Vieira, Mary L. Marazita

Research output: Contribution to journalArticle

Abstract

Dental caries (tooth decay) is the most common chronic disease, worldwide, affecting most children and adults. Though dental caries is highly heritable, few caries-related genes have been discovered. We investigated whether 18 genetic variants in the group of non-amelogenin enamel matrix genes (AMBN, ENAM, TUFT1, and TFIP11) were associated with dental caries experience in 13 age- and race-stratified samples from six parent studies (N = 3,600). Linear regression was used to model genetic associations and test gene-by-fluoride interaction effects for two sources of fluoride: daily tooth brushing and home water fluoride concentration. Meta-analysis was used to combine results across five child and eight adult samples. We observed the statistically significant association of rs2337359 upstream of TUFT1 with dental caries experience via meta-analysis across adult samples (p 

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalHuman Genetics
Volume134
Issue number2
DOIs
StatePublished - 2015

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Dental Caries
Dental Enamel
Fluorides
Genes
Meta-Analysis
Tooth
Genetic Models
Linear Models
Chronic Disease
Water

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Shaffer, J. R., Carlson, J. C., Stanley, B. O. C., Feingold, E., Cooper, M., Vanyukov, M. M., ... Marazita, M. L. (2015). Effects of enamel matrix genes on dental caries are moderated by fluoride exposures. Human Genetics, 134(2), 159-167. https://doi.org/10.1007/s00439-014-1504-7

Effects of enamel matrix genes on dental caries are moderated by fluoride exposures. / Shaffer, John R.; Carlson, Jenna C.; Stanley, Brooklyn O C; Feingold, Eleanor; Cooper, Margaret; Vanyukov, Michael M.; Maher, Brion; Slayton, Rebecca L.; Willing, Marcia C.; Reis, Steven E.; McNeil, Daniel W.; Crout, Richard J.; Weyant, Robert J.; Levy, Steven M.; Vieira, Alexandre R.; Marazita, Mary L.

In: Human Genetics, Vol. 134, No. 2, 2015, p. 159-167.

Research output: Contribution to journalArticle

Shaffer, JR, Carlson, JC, Stanley, BOC, Feingold, E, Cooper, M, Vanyukov, MM, Maher, B, Slayton, RL, Willing, MC, Reis, SE, McNeil, DW, Crout, RJ, Weyant, RJ, Levy, SM, Vieira, AR & Marazita, ML 2015, 'Effects of enamel matrix genes on dental caries are moderated by fluoride exposures', Human Genetics, vol. 134, no. 2, pp. 159-167. https://doi.org/10.1007/s00439-014-1504-7
Shaffer JR, Carlson JC, Stanley BOC, Feingold E, Cooper M, Vanyukov MM et al. Effects of enamel matrix genes on dental caries are moderated by fluoride exposures. Human Genetics. 2015;134(2):159-167. https://doi.org/10.1007/s00439-014-1504-7
Shaffer, John R. ; Carlson, Jenna C. ; Stanley, Brooklyn O C ; Feingold, Eleanor ; Cooper, Margaret ; Vanyukov, Michael M. ; Maher, Brion ; Slayton, Rebecca L. ; Willing, Marcia C. ; Reis, Steven E. ; McNeil, Daniel W. ; Crout, Richard J. ; Weyant, Robert J. ; Levy, Steven M. ; Vieira, Alexandre R. ; Marazita, Mary L. / Effects of enamel matrix genes on dental caries are moderated by fluoride exposures. In: Human Genetics. 2015 ; Vol. 134, No. 2. pp. 159-167.
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