TY - JOUR
T1 - Effects of Electroconvulsive Shock on Tetrahydrobiopterin and GTP‐Cyclohydrolase Activity in the Brain and Adrenal Gland of the Rat
AU - Hossain, Mir Ahamed
AU - Masserano, Joseph M.
AU - Weiner, Norman
PY - 1992/12
Y1 - 1992/12
N2 - Abstract: The effects of a single and repeated electroconvulsive shock (ECS) (300 mA, 0.2 s) on tetrahydrobiopterin (BH4) levels and GTP‐cyclohydrolase activity in the brain and adrenal glands of rats were examined. Twenty‐four hours after the last ECS treatment (one/day for 7 days), biopterin levels were significantly elevated in the locus coeruleus, hippocampus, frontal cortex, hypothalamus, ventral tegmental area, and adrenal gland. There were no changes in biopterin levels after a single application of ECS. GTP‐cyclohydrolase activity was significantly increased in the locus coeruleus, frontal cortex, hippocampus, hypothalamus, and adrenal gland 24 h after repeated ECS and remained elevated in certain tissues up to 8 days after the last treatment. Kinetic analysis of adrenal and locus coeruleus GTP‐cyclohydrolase 1 day after 7 days of ECS showed significant changes in both Km and Vmax values. These data suggest that the long‐term increases in BH4 levels and GTP‐cyclohydrolase activity after repeated ECS may play a part in the mediation of the antidepressant effects of ECS.
AB - Abstract: The effects of a single and repeated electroconvulsive shock (ECS) (300 mA, 0.2 s) on tetrahydrobiopterin (BH4) levels and GTP‐cyclohydrolase activity in the brain and adrenal glands of rats were examined. Twenty‐four hours after the last ECS treatment (one/day for 7 days), biopterin levels were significantly elevated in the locus coeruleus, hippocampus, frontal cortex, hypothalamus, ventral tegmental area, and adrenal gland. There were no changes in biopterin levels after a single application of ECS. GTP‐cyclohydrolase activity was significantly increased in the locus coeruleus, frontal cortex, hippocampus, hypothalamus, and adrenal gland 24 h after repeated ECS and remained elevated in certain tissues up to 8 days after the last treatment. Kinetic analysis of adrenal and locus coeruleus GTP‐cyclohydrolase 1 day after 7 days of ECS showed significant changes in both Km and Vmax values. These data suggest that the long‐term increases in BH4 levels and GTP‐cyclohydrolase activity after repeated ECS may play a part in the mediation of the antidepressant effects of ECS.
KW - Adrenal gland
KW - CNS
KW - Electroconvulsive shock
KW - GTP‐cyclohydrolase
KW - Tetrahydrobiopterin
KW - Tyrosine hydroxylase
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U2 - 10.1111/j.1471-4159.1992.tb10116.x
DO - 10.1111/j.1471-4159.1992.tb10116.x
M3 - Article
C2 - 1431904
AN - SCOPUS:0026564363
VL - 59
SP - 2237
EP - 2243
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 6
ER -