Effects of electroconvulsive shock on tetrahydrobiopterin and GTP-cyclohydrolase activity in the brain and adrenal gland of the rat

Mir Ahamed Hossain, Joseph M. Masserano, Norman Weiner

Research output: Contribution to journalArticle

Abstract

The effects of a single and repeated electroconvulsive shock (ECS) (300 mA, 0.2 s) on tetrahydrobiopterin (BH4) levels and GTP-cyclohydrolase activity in the brain and adrenal glands of rats were examined. Twenty-four hours after the last ECS treatment (one/day for 7 days), biopterin levels were significantly elevated in the locus coeruleus, hippocampus, frontal cortex, hypothalamus, ventral tegmental area, and adrenal gland. There were no changes in biopterin levels after a single application of ECS. GTP-cyclohydrolase activity was significantly increased in the locus coeruleus, frontal cortex, hippocampus, hypothalamus, and adrenal gland 24 h after repeated ECS and remained elevated in certain tissues up to 8 days after the last treatment. Kinetic analysis of adrenal and locus coeruleus GTP-cyclohydrolase 1 day after 7 days of ECS showed significant changes in both Km and Vmax values. These data suggest that the long-term increases in BH4 levels and GTP-cyclohydrolase activity after repeated ECS may play a part in the mediation of the antidepressant effects of ECS.

Original languageEnglish (US)
Pages (from-to)2237-2243
Number of pages7
JournalJournal of Neurochemistry
Volume59
Issue number6
StatePublished - Dec 1992
Externally publishedYes

Fingerprint

GTP Cyclohydrolase
Electroshock
Adrenal Glands
Rats
Brain
Biopterin
Locus Coeruleus
Frontal Lobe
Hypothalamus
Hippocampus
Antidepressive Agents
Ventral Tegmental Area
Tissue
Kinetics
sapropterin

Keywords

  • Adrenal gland
  • CNS
  • Electroconvulsive shock
  • GTP-cyclohydrolase
  • Tetrahydrobiopterin
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Effects of electroconvulsive shock on tetrahydrobiopterin and GTP-cyclohydrolase activity in the brain and adrenal gland of the rat. / Hossain, Mir Ahamed; Masserano, Joseph M.; Weiner, Norman.

In: Journal of Neurochemistry, Vol. 59, No. 6, 12.1992, p. 2237-2243.

Research output: Contribution to journalArticle

Hossain, Mir Ahamed ; Masserano, Joseph M. ; Weiner, Norman. / Effects of electroconvulsive shock on tetrahydrobiopterin and GTP-cyclohydrolase activity in the brain and adrenal gland of the rat. In: Journal of Neurochemistry. 1992 ; Vol. 59, No. 6. pp. 2237-2243.
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