Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs

Y. Lei, Jiande Chen

Research output: Contribution to journalArticle

Abstract

Background: Gastric electrical stimulation (GES) with short pulses improves nausea and vomiting in patients with gastroparesis, whereas GES with long pulses improves gastric motility. Aims: To assess the effects of a novel method of GES using dual pulse (both short and long pulses) on gastric tone, compliance and sympathovagal activity in dogs. Materials and methods: The study was performed in 7 dogs implanted with a gastric cannula and a pair of gastric serosal electrodes for dual pulse GES. The study was composed of a number of sessions on different days with different stimulation parameters, including variations in the number of short pulses and stimulation amplitude. Results: (1) Dual pulse GES of one short pulse and one long pulse with various amplitudes inhibited gastric tone (p <0.05) but did not alter sympathetic or vagal activity. (2) Dual pulse GES with five short pulses and one long pulse not only inhibited gastric tone, but also reduced sympathetic activity and increased vagal activity (p <0.05). (3) Dual pulse GES with five short pulses and one long pulse significantly increased gastric compliance. Conclusions: Dual pulse GES reduces gastric tone and increases gastric compliance. The variation in the number of short pulse affects the sympathetic and vagal activities, whereas, the increase in stimulation strength enhances its effects on gastric tone.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalDigestive and Liver Disease
Volume41
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Electric Stimulation
Compliance
Stomach
Dogs
Gastroparesis
Nausea
Vomiting

Keywords

  • Gastric compliance
  • Gastric electrical stimulation
  • Gastric tone
  • Sympathetic and vagal activity

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs. / Lei, Y.; Chen, Jiande.

In: Digestive and Liver Disease, Vol. 41, No. 4, 04.2009, p. 277-282.

Research output: Contribution to journalArticle

@article{c4cd1e5302274269a204605c41655d66,
title = "Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs",
abstract = "Background: Gastric electrical stimulation (GES) with short pulses improves nausea and vomiting in patients with gastroparesis, whereas GES with long pulses improves gastric motility. Aims: To assess the effects of a novel method of GES using dual pulse (both short and long pulses) on gastric tone, compliance and sympathovagal activity in dogs. Materials and methods: The study was performed in 7 dogs implanted with a gastric cannula and a pair of gastric serosal electrodes for dual pulse GES. The study was composed of a number of sessions on different days with different stimulation parameters, including variations in the number of short pulses and stimulation amplitude. Results: (1) Dual pulse GES of one short pulse and one long pulse with various amplitudes inhibited gastric tone (p <0.05) but did not alter sympathetic or vagal activity. (2) Dual pulse GES with five short pulses and one long pulse not only inhibited gastric tone, but also reduced sympathetic activity and increased vagal activity (p <0.05). (3) Dual pulse GES with five short pulses and one long pulse significantly increased gastric compliance. Conclusions: Dual pulse GES reduces gastric tone and increases gastric compliance. The variation in the number of short pulse affects the sympathetic and vagal activities, whereas, the increase in stimulation strength enhances its effects on gastric tone.",
keywords = "Gastric compliance, Gastric electrical stimulation, Gastric tone, Sympathetic and vagal activity",
author = "Y. Lei and Jiande Chen",
year = "2009",
month = "4",
doi = "10.1016/j.dld.2008.07.312",
language = "English (US)",
volume = "41",
pages = "277--282",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs

AU - Lei, Y.

AU - Chen, Jiande

PY - 2009/4

Y1 - 2009/4

N2 - Background: Gastric electrical stimulation (GES) with short pulses improves nausea and vomiting in patients with gastroparesis, whereas GES with long pulses improves gastric motility. Aims: To assess the effects of a novel method of GES using dual pulse (both short and long pulses) on gastric tone, compliance and sympathovagal activity in dogs. Materials and methods: The study was performed in 7 dogs implanted with a gastric cannula and a pair of gastric serosal electrodes for dual pulse GES. The study was composed of a number of sessions on different days with different stimulation parameters, including variations in the number of short pulses and stimulation amplitude. Results: (1) Dual pulse GES of one short pulse and one long pulse with various amplitudes inhibited gastric tone (p <0.05) but did not alter sympathetic or vagal activity. (2) Dual pulse GES with five short pulses and one long pulse not only inhibited gastric tone, but also reduced sympathetic activity and increased vagal activity (p <0.05). (3) Dual pulse GES with five short pulses and one long pulse significantly increased gastric compliance. Conclusions: Dual pulse GES reduces gastric tone and increases gastric compliance. The variation in the number of short pulse affects the sympathetic and vagal activities, whereas, the increase in stimulation strength enhances its effects on gastric tone.

AB - Background: Gastric electrical stimulation (GES) with short pulses improves nausea and vomiting in patients with gastroparesis, whereas GES with long pulses improves gastric motility. Aims: To assess the effects of a novel method of GES using dual pulse (both short and long pulses) on gastric tone, compliance and sympathovagal activity in dogs. Materials and methods: The study was performed in 7 dogs implanted with a gastric cannula and a pair of gastric serosal electrodes for dual pulse GES. The study was composed of a number of sessions on different days with different stimulation parameters, including variations in the number of short pulses and stimulation amplitude. Results: (1) Dual pulse GES of one short pulse and one long pulse with various amplitudes inhibited gastric tone (p <0.05) but did not alter sympathetic or vagal activity. (2) Dual pulse GES with five short pulses and one long pulse not only inhibited gastric tone, but also reduced sympathetic activity and increased vagal activity (p <0.05). (3) Dual pulse GES with five short pulses and one long pulse significantly increased gastric compliance. Conclusions: Dual pulse GES reduces gastric tone and increases gastric compliance. The variation in the number of short pulse affects the sympathetic and vagal activities, whereas, the increase in stimulation strength enhances its effects on gastric tone.

KW - Gastric compliance

KW - Gastric electrical stimulation

KW - Gastric tone

KW - Sympathetic and vagal activity

UR - http://www.scopus.com/inward/record.url?scp=62049085012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62049085012&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2008.07.312

DO - 10.1016/j.dld.2008.07.312

M3 - Article

C2 - 18799372

AN - SCOPUS:62049085012

VL - 41

SP - 277

EP - 282

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 4

ER -