Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites

Jose Musacchio, Irwin J. Kopin, Solomon Snyder

Research output: Contribution to journalArticle

Abstract

Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.

Original languageEnglish (US)
Pages (from-to)769-775
Number of pages7
JournalLife Sciences
Volume3
Issue number7
DOIs
StatePublished - Jul 1964

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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