Effects of different nicotine replacement therapies on postcessation psychological responses

Andrew A. Strasser; Vyga Kaufmann; Christopher Jepson; Kenneth A. Perkins; Wallace B. Pickworth; E. Paul Wileyto; Margaret Rukstalis; Janet Audrain-Mcgovern; Caryn Lerman

doi:10.1016/j.addbeh.2004.04.005

Effects of different nicotine replacement therapies on postcessation psychological responses

Andrew A. Strasser, Vyga Kaufmann, Christopher Jepson, Kenneth A. Perkins, Wallace B. Pickworth, E. Paul Wileyto, Margaret Rukstalis, Janet Audrain-Mcgovern, Caryn Lerman

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Transdermal nicotine patch (TN) and nicotine nasal spray (NS) are both efficacious forms of smoking cessation treatment, but have different pharmacokinetic properties and modes of action. To understand better psychological responses to treatment, we investigated the effects of TN versus NS on positive affect, negative affect, and withdrawal symptoms during treatment. Participants were randomly assigned to receive TN (n=172) or NS (n=163) plus seven sessions of behavioral counseling, and completed self-report questionnaires at pretreatment and during treatment. TN participants, but not NS participants, reported significant increases in positive affect during treatment. Increases in negative affect and withdrawal were observed, independent of treatment. Only changes in negative affect predicted relapse by the end of the treatment phase. These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome.

Original language	English (US)
Pages (from-to)	9-17
Number of pages	9
Journal	Addictive Behaviors
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.addbeh.2004.04.005
State	Published - Jan 2005
Externally published	Yes

Keywords

Nicotine replacement therapy
Postcessation
Psychological

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Toxicology
Psychiatry and Mental health

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10.1016/j.addbeh.2004.04.005

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title = "Effects of different nicotine replacement therapies on postcessation psychological responses",

abstract = "Transdermal nicotine patch (TN) and nicotine nasal spray (NS) are both efficacious forms of smoking cessation treatment, but have different pharmacokinetic properties and modes of action. To understand better psychological responses to treatment, we investigated the effects of TN versus NS on positive affect, negative affect, and withdrawal symptoms during treatment. Participants were randomly assigned to receive TN (n=172) or NS (n=163) plus seven sessions of behavioral counseling, and completed self-report questionnaires at pretreatment and during treatment. TN participants, but not NS participants, reported significant increases in positive affect during treatment. Increases in negative affect and withdrawal were observed, independent of treatment. Only changes in negative affect predicted relapse by the end of the treatment phase. These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome.",

keywords = "Nicotine replacement therapy, Postcessation, Psychological",

author = "Strasser, {Andrew A.} and Vyga Kaufmann and Christopher Jepson and Perkins, {Kenneth A.} and Pickworth, {Wallace B.} and Wileyto, {E. Paul} and Margaret Rukstalis and Janet Audrain-Mcgovern and Caryn Lerman",

note = "Funding Information: This work was supported by a Transdisciplinary Tobacco Use Research Center Grant from the National Cancer Institute and the National Institute on Drug Abuse CA/DA P5084718 (Lerman) and a Public Health Services Research Grant M01-RR0040 from the National Institutes of Health.",

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language = "English (US)",

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AU - Jepson, Christopher

AU - Perkins, Kenneth A.

AU - Pickworth, Wallace B.

AU - Wileyto, E. Paul

AU - Rukstalis, Margaret

AU - Audrain-Mcgovern, Janet

AU - Lerman, Caryn

N1 - Funding Information: This work was supported by a Transdisciplinary Tobacco Use Research Center Grant from the National Cancer Institute and the National Institute on Drug Abuse CA/DA P5084718 (Lerman) and a Public Health Services Research Grant M01-RR0040 from the National Institutes of Health.

PY - 2005/1

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N2 - Transdermal nicotine patch (TN) and nicotine nasal spray (NS) are both efficacious forms of smoking cessation treatment, but have different pharmacokinetic properties and modes of action. To understand better psychological responses to treatment, we investigated the effects of TN versus NS on positive affect, negative affect, and withdrawal symptoms during treatment. Participants were randomly assigned to receive TN (n=172) or NS (n=163) plus seven sessions of behavioral counseling, and completed self-report questionnaires at pretreatment and during treatment. TN participants, but not NS participants, reported significant increases in positive affect during treatment. Increases in negative affect and withdrawal were observed, independent of treatment. Only changes in negative affect predicted relapse by the end of the treatment phase. These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome.

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Effects of different nicotine replacement therapies on postcessation psychological responses

Abstract

Keywords

ASJC Scopus subject areas

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