Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: The Dietary Intervention Study in Children (DISC)

Peter O. Kwiterovich, Bruce A. Barton, Robert P. McMahon, Eva Obarzanek, Sally Hunsberger, Denise Simons-Morton, Sue Y S Kimm, Lisa Aronson Friedman, Norman Lasser, Alan Robson, Ronald Lauer, Victor Stevens, Linda Van Horn, Samuel Gidding, Linda Snetselaar, Virginia W. Hartmuller, Merwyn Greenlick, Frank Franklin

Research output: Contribution to journalArticle

Abstract

Background: The Dietary Intervention Study in Children (DISC) is a multicenter, randomized, controlled clinical trial designed to examine the efficacy and safety of a dietary intervention to reduce serum LDL cholesterol (LDL-C) in children with elevated LDL-C. Methods and Results: The effects of dietary intake of fat and cholesterol and of sexual maturation and body mass index (BMI) on LDL-C were examined in a 3-year longitudinal study of 663 boys and girls (age 8 to 10 years at baseline) with elevated LDL-C levels. Multiple linear regression was used to predict LDL-C at 3 years. For boys, LDL-C decreased by 0.018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P

Original languageEnglish (US)
Pages (from-to)2526-2533
Number of pages8
JournalCirculation
Volume96
Issue number8
Publication statusPublished - Oct 21 1997

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Keywords

  • Coronary disease
  • Diet hyperlipoproteinemia
  • Lipoproteins
  • Pediatrics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kwiterovich, P. O., Barton, B. A., McMahon, R. P., Obarzanek, E., Hunsberger, S., Simons-Morton, D., ... Franklin, F. (1997). Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: The Dietary Intervention Study in Children (DISC). Circulation, 96(8), 2526-2533.