Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551

Anup K. Kesavan, Susana E. Mendez, Christine L. Hatem, Javier Lopez-Molina, Katherine Aird, M. Louise M. Pitt, Arthur M. Dannenberg, Yukari C. Manabe

Research output: Contribution to journalArticlepeer-review

Abstract

Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolized Mycobacterium tuberculosis that subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.

Original languageEnglish (US)
Pages (from-to)7056-7060
Number of pages5
JournalInfection and immunity
Volume73
Issue number10
DOIs
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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