Effects of deworming on child and maternal health

A literature review and meta-analysis

Winter Maxwell Thayer, Adrienne Clermont, Neff Walker

Research output: Contribution to journalArticle

Abstract

Background: Soil-transmitted helminth infections are widespread. Many studies have been published on the topic of deworming. The Lives Saved Tool (LiST) is a software package that uses a deterministic mathematical model to estimate the effect of scaling up interventions on maternal and child health outcomes. This review investigates the scope of available evidence for benefits of deworming treatments in order to inform a decision about possible inclusion of deworming as an intervention in LiST. Methods: We searched PubMed, the Cochrane Library, and Google Scholar. We included studies that reported pre/post data in children younger than 5 years or pregnant women for outcomes related to mortality and growth. We excluded studies that compared different anthelminthic treatments but did not include a placebo or non-treatment group, and those that did not report post-intervention outcomes. We categorized articles by treated population (children younger than 5 years and pregnant women), experimental versus observational, mass drug administration (MDA) versus treatment, and reported outcome. Results: We identified 58 relevant trials; 27 investigated children younger than 5 years and 11 investigated pregnant women; one reported on both children younger than 5 years and pregnant women. We conducted meta-analyses of relevant outcomes in children younger than 5 years. Conclusions: Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age. We do not recommend including the effect of deworming in the LiST model.

Original languageEnglish (US)
Article number830
JournalBMC Public Health
Volume17
DOIs
StatePublished - Nov 7 2017

Fingerprint

Meta-Analysis
Pregnant Women
Mortality
Helminths
Growth
PubMed
Libraries
Maternal Health
Child Health
Anemia
Theoretical Models
Soil
Software
Placebos
Therapeutics
Infection
Pharmaceutical Preparations
Population

Keywords

  • Anemia
  • Ascaris
  • Child health
  • Hookworm
  • Malnutrition
  • Maternal health
  • Soil-transmitted helminth
  • Stunting
  • Trichuris
  • Wasting

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Effects of deworming on child and maternal health : A literature review and meta-analysis. / Thayer, Winter Maxwell; Clermont, Adrienne; Walker, Neff.

In: BMC Public Health, Vol. 17, 830, 07.11.2017.

Research output: Contribution to journalArticle

@article{b0a2c2b25fad414899b1733854032a9f,
title = "Effects of deworming on child and maternal health: A literature review and meta-analysis",
abstract = "Background: Soil-transmitted helminth infections are widespread. Many studies have been published on the topic of deworming. The Lives Saved Tool (LiST) is a software package that uses a deterministic mathematical model to estimate the effect of scaling up interventions on maternal and child health outcomes. This review investigates the scope of available evidence for benefits of deworming treatments in order to inform a decision about possible inclusion of deworming as an intervention in LiST. Methods: We searched PubMed, the Cochrane Library, and Google Scholar. We included studies that reported pre/post data in children younger than 5 years or pregnant women for outcomes related to mortality and growth. We excluded studies that compared different anthelminthic treatments but did not include a placebo or non-treatment group, and those that did not report post-intervention outcomes. We categorized articles by treated population (children younger than 5 years and pregnant women), experimental versus observational, mass drug administration (MDA) versus treatment, and reported outcome. Results: We identified 58 relevant trials; 27 investigated children younger than 5 years and 11 investigated pregnant women; one reported on both children younger than 5 years and pregnant women. We conducted meta-analyses of relevant outcomes in children younger than 5 years. Conclusions: Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age. We do not recommend including the effect of deworming in the LiST model.",
keywords = "Anemia, Ascaris, Child health, Hookworm, Malnutrition, Maternal health, Soil-transmitted helminth, Stunting, Trichuris, Wasting",
author = "Thayer, {Winter Maxwell} and Adrienne Clermont and Neff Walker",
year = "2017",
month = "11",
day = "7",
doi = "10.1186/s12889-017-4747-0",
language = "English (US)",
volume = "17",
journal = "BMC Public Health",
issn = "1471-2458",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Effects of deworming on child and maternal health

T2 - A literature review and meta-analysis

AU - Thayer, Winter Maxwell

AU - Clermont, Adrienne

AU - Walker, Neff

PY - 2017/11/7

Y1 - 2017/11/7

N2 - Background: Soil-transmitted helminth infections are widespread. Many studies have been published on the topic of deworming. The Lives Saved Tool (LiST) is a software package that uses a deterministic mathematical model to estimate the effect of scaling up interventions on maternal and child health outcomes. This review investigates the scope of available evidence for benefits of deworming treatments in order to inform a decision about possible inclusion of deworming as an intervention in LiST. Methods: We searched PubMed, the Cochrane Library, and Google Scholar. We included studies that reported pre/post data in children younger than 5 years or pregnant women for outcomes related to mortality and growth. We excluded studies that compared different anthelminthic treatments but did not include a placebo or non-treatment group, and those that did not report post-intervention outcomes. We categorized articles by treated population (children younger than 5 years and pregnant women), experimental versus observational, mass drug administration (MDA) versus treatment, and reported outcome. Results: We identified 58 relevant trials; 27 investigated children younger than 5 years and 11 investigated pregnant women; one reported on both children younger than 5 years and pregnant women. We conducted meta-analyses of relevant outcomes in children younger than 5 years. Conclusions: Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age. We do not recommend including the effect of deworming in the LiST model.

AB - Background: Soil-transmitted helminth infections are widespread. Many studies have been published on the topic of deworming. The Lives Saved Tool (LiST) is a software package that uses a deterministic mathematical model to estimate the effect of scaling up interventions on maternal and child health outcomes. This review investigates the scope of available evidence for benefits of deworming treatments in order to inform a decision about possible inclusion of deworming as an intervention in LiST. Methods: We searched PubMed, the Cochrane Library, and Google Scholar. We included studies that reported pre/post data in children younger than 5 years or pregnant women for outcomes related to mortality and growth. We excluded studies that compared different anthelminthic treatments but did not include a placebo or non-treatment group, and those that did not report post-intervention outcomes. We categorized articles by treated population (children younger than 5 years and pregnant women), experimental versus observational, mass drug administration (MDA) versus treatment, and reported outcome. Results: We identified 58 relevant trials; 27 investigated children younger than 5 years and 11 investigated pregnant women; one reported on both children younger than 5 years and pregnant women. We conducted meta-analyses of relevant outcomes in children younger than 5 years. Conclusions: Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age. We do not recommend including the effect of deworming in the LiST model.

KW - Anemia

KW - Ascaris

KW - Child health

KW - Hookworm

KW - Malnutrition

KW - Maternal health

KW - Soil-transmitted helminth

KW - Stunting

KW - Trichuris

KW - Wasting

UR - http://www.scopus.com/inward/record.url?scp=85032975371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032975371&partnerID=8YFLogxK

U2 - 10.1186/s12889-017-4747-0

DO - 10.1186/s12889-017-4747-0

M3 - Article

VL - 17

JO - BMC Public Health

JF - BMC Public Health

SN - 1471-2458

M1 - 830

ER -