Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

N. T.F. Leite; R. Salvatori; M. R.S. Alcântara; P. R.S. Alcântara; C. R.P. Oliveira; J. L.M. Oliveira; F. D. Anjos-Andrade; M. I.T. Farias; C. T.F. Britto; L. M.A. Nóbrega; A. C. Nascimento-Junior; É O. Alves; R. M.C. Pereira; V. C. Campos; M. Menezes; C. E. Martinelli-Júnior; M. H. Aguiar-Oliveira

doi:10.3275/7608

Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

N. T.F. Leite, R. Salvatori, M. R.S. Alcântara, P. R.S. Alcântara, C. R.P. Oliveira, J. L.M. Oliveira, F. D. Anjos-Andrade, M. I.T. Farias, C. T.F. Britto, L. M.A. Nóbrega, A. C. Nascimento-Junior, É O. Alves, R. M.C. Pereira, V. C. Campos, M. Menezes, C. E. Martinelli-Júnior, M. H. Aguiar-Oliveira

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T ₃, free T ₄ (FT ₄), reverse T ₃ (rT ₃), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T ₃ increased pGH. T ₃ levels remained elevated at 6mo. GHRT did not significantly change FT ₄, rT ₃, TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T ₃ levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.

Original language	English (US)
Pages (from-to)	265-268
Number of pages	4
Journal	Journal of endocrinological investigation
Volume	35
Issue number	3
DOIs	https://doi.org/10.3275/7608
State	Published - Mar 2012

Keywords

Free thyroxine
Growth hormone replacement therapy
Isolated growth hormone deficiency
Thyroid
Thyroid volume

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.3275/7608

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Leite, N. T. F., Salvatori, R., Alcântara, M. R. S., Alcântara, P. R. S., Oliveira, C. R. P., Oliveira, J. L. M., Anjos-Andrade, F. D., Farias, M. I. T., Britto, C. T. F., Nóbrega, L. M. A., Nascimento-Junior, A. C., Alves, É. O., Pereira, R. M. C., Campos, V. C., Menezes, M., Martinelli-Júnior, C. E., & Aguiar-Oliveira, M. H. (2012). Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency. Journal of endocrinological investigation, 35(3), 265-268. https://doi.org/10.3275/7608

Leite, NTF, Salvatori, R, Alcântara, MRS, Alcântara, PRS, Oliveira, CRP, Oliveira, JLM, Anjos-Andrade, FD, Farias, MIT, Britto, CTF, Nóbrega, LMA, Nascimento-Junior, AC, Alves, ÉO, Pereira, RMC, Campos, VC, Menezes, M, Martinelli-Júnior, CE & Aguiar-Oliveira, MH 2012, 'Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency', Journal of endocrinological investigation, vol. 35, no. 3, pp. 265-268. https://doi.org/10.3275/7608

@article{43a81be0fae64041981386f480438cf7,

title = "Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency",

abstract = "Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-na{\"i}ve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T 3, free T 4 (FT 4), reverse T 3 (rT 3), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T 3 increased pGH. T 3 levels remained elevated at 6mo. GHRT did not significantly change FT 4, rT 3, TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T 3 levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.",

keywords = "Free thyroxine, Growth hormone replacement therapy, Isolated growth hormone deficiency, Thyroid, Thyroid volume",

author = "Leite, {N. T.F.} and R. Salvatori and Alc{\^a}ntara, {M. R.S.} and Alc{\^a}ntara, {P. R.S.} and Oliveira, {C. R.P.} and Oliveira, {J. L.M.} and Anjos-Andrade, {F. D.} and Farias, {M. I.T.} and Britto, {C. T.F.} and N{\'o}brega, {L. M.A.} and Nascimento-Junior, {A. C.} and Alves, {{\'E} O.} and Pereira, {R. M.C.} and Campos, {V. C.} and M. Menezes and Martinelli-J{\'u}nior, {C. E.} and Aguiar-Oliveira, {M. H.}",

note = "Funding Information: We are grateful to Mrs. Ivanilde Santana de Sousa for her secretarial assistance. Supported by NIH Grant 1 R01 DK065718, by a grant from the Genentech Center for Clinical Research in Endocrinology (both to R.S.), and by grant BEX 4309/08-1 from CAPES “Coordena{\c c}{\~a}o de Aperfei{\c c}oa-mento de Pessoal de N{\'i}vel Superior”, from the Brazilian Government (to M.H.A-O.).",

year = "2012",

month = mar,

doi = "10.3275/7608",

language = "English (US)",

volume = "35",

pages = "265--268",

journal = "Journal of endocrinological investigation",

issn = "0391-4097",

publisher = "Editrice Kurtis s.r.l.",

number = "3",

}

TY - JOUR

T1 - Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

AU - Leite, N. T.F.

AU - Salvatori, R.

AU - Alcântara, M. R.S.

AU - Alcântara, P. R.S.

AU - Oliveira, C. R.P.

AU - Oliveira, J. L.M.

AU - Anjos-Andrade, F. D.

AU - Farias, M. I.T.

AU - Britto, C. T.F.

AU - Nóbrega, L. M.A.

AU - Nascimento-Junior, A. C.

AU - Alves, É O.

AU - Pereira, R. M.C.

AU - Campos, V. C.

AU - Menezes, M.

AU - Martinelli-Júnior, C. E.

AU - Aguiar-Oliveira, M. H.

N1 - Funding Information: We are grateful to Mrs. Ivanilde Santana de Sousa for her secretarial assistance. Supported by NIH Grant 1 R01 DK065718, by a grant from the Genentech Center for Clinical Research in Endocrinology (both to R.S.), and by grant BEX 4309/08-1 from CAPES “Coordenação de Aperfeiçoa-mento de Pessoal de Nível Superior”, from the Brazilian Government (to M.H.A-O.).

PY - 2012/3

Y1 - 2012/3

N2 - Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T 3, free T 4 (FT 4), reverse T 3 (rT 3), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T 3 increased pGH. T 3 levels remained elevated at 6mo. GHRT did not significantly change FT 4, rT 3, TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T 3 levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.

AB - Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T 3, free T 4 (FT 4), reverse T 3 (rT 3), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T 3 increased pGH. T 3 levels remained elevated at 6mo. GHRT did not significantly change FT 4, rT 3, TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T 3 levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.

KW - Free thyroxine

KW - Growth hormone replacement therapy

KW - Isolated growth hormone deficiency

KW - Thyroid

KW - Thyroid volume

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U2 - 10.3275/7608

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M3 - Article

C2 - 21422802

AN - SCOPUS:84862731864

SN - 0391-4097

VL - 35

SP - 265

EP - 268

JO - Journal of endocrinological investigation

JF - Journal of endocrinological investigation

IS - 3

ER -

Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

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