Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

N. T.F. Leite, R. Salvatori, M. R.S. Alcântara, P. R.S. Alcântara, C. R.P. Oliveira, J. L.M. Oliveira, F. D. Anjos-Andrade, M. I.T. Farias, C. T.F. Britto, L. M.A. Nóbrega, A. C. Nascimento-Junior, É O. Alves, R. M.C. Pereira, V. C. Campos, M. Menezes, C. E. Martinelli-Júnior, M. H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T 3, free T 4 (FT 4), reverse T 3 (rT 3), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T 3 increased pGH. T 3 levels remained elevated at 6mo. GHRT did not significantly change FT 4, rT 3, TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T 3 levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalJournal of endocrinological investigation
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Free thyroxine
  • Growth hormone replacement therapy
  • Isolated growth hormone deficiency
  • Thyroid
  • Thyroid volume

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Leite, N. T. F., Salvatori, R., Alcântara, M. R. S., Alcântara, P. R. S., Oliveira, C. R. P., Oliveira, J. L. M., Anjos-Andrade, F. D., Farias, M. I. T., Britto, C. T. F., Nóbrega, L. M. A., Nascimento-Junior, A. C., Alves, É. O., Pereira, R. M. C., Campos, V. C., Menezes, M., Martinelli-Júnior, C. E., & Aguiar-Oliveira, M. H. (2012). Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency. Journal of endocrinological investigation, 35(3), 265-268. https://doi.org/10.3275/7608