Effects of deep brain stimulation on adaptive control of reaching

Haiyin Chen, Maurice A. Smith, Reza Shadmehr

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lesion or degeneration of the cerebellum can profoundly impair adaptive control of reaching in humans. Computational models have proposed that internal models for motor action form in the cerebellum and influence planned motor output through the cerebello-thalamo-cortical pathway. However, lesions in the cerebellar thalamus have not been consistently shown to result in motor adaptation impairment. To elucidate the role of the cerebellar thalamus in humans, we studied a group of essential tremor (ET) patients with deep brain stimulation (DBS) electrodes placed in the cerebellar thalamus. The stimulation can be turned on or off remotely, and is thought to reduce tremor by blocking the spread of the pathological output from the cerebellum. We found that while thalamic DBS resulted in a dramatic reduction in ET, it also led to impaired motor adaptation in the patients. Thus, human adaptive reaching motor control depends on the integrity of the thalamic nucleus that relays cerebellar output to the cerebral cortex.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages5445-5448
Number of pages4
StatePublished - Dec 1 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Chen, H., Smith, M. A., & Shadmehr, R. (2005). Effects of deep brain stimulation on adaptive control of reaching. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 5445-5448). [1615715] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).