Abstract
The killing efficiency due to the decay of incorporated H3-thymidine in three mutants of E. coli strain 15: 15T-, 15T-L-, and 15T-U- has been determined. This efficiency is comparable to that previously determined by others for P32 decay. The killing efficiency has been determined as a function of H3-thymidine specific activity, storage media and storage temperature. We have observed a latent killing effect that causes lethality under certain conditions. The kinetics of latent killing have been examined at several temperatures. Finally, mutation production induced by H3-thymidine decays was shown to occur. The results are consistent with the idea that inactivation and mutations may be caused by a process in the nuclear transmutation that is not associated with β-particle ionization damage.
Original language | English (US) |
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Pages (from-to) | 451-463 |
Number of pages | 13 |
Journal | Biophysical journal |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - 1962 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics