Effects of d-methamphetamine on auditory and visual reaction times and detection thresholds in the baboon

Robert D. Hienz, Scott E. Lukas, Joseph V. Brady

Research output: Contribution to journalArticle

Abstract

Baboons were trained in both auditory and visual reaction time procedures to release a response lever in the presence of low-intensity stimuli. By varying the stimulus intensity from trial to trial, functions relating reaction time (elapsed time from stimulus onset to lever release) to stimulus intensity were established, and detection thresholds were measured. The effects of acute, IM injections of d-methamphetamine (0.001-1.0 mg/kg) were examined on these psychophysical performance baselines. Reaction times for acoustic stimuli generally were faster for higher drug doses, whereas reaction times for visual stimuli either lengthened or shortened, depending on both drug dose and individual differences among animals. Auditory thresholds were unaffected at all drug doses studied, whereas visual thresholds were generally elevated at doses of 0.1 mg/kg and above.

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalPsychopharmacology
Volume85
Issue number4
DOIs
StatePublished - Apr 1 1985

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Keywords

  • Auditory thresholds
  • Baboon
  • Reaction time
  • Visual thresholds
  • d-Methamphetamine

ASJC Scopus subject areas

  • Pharmacology

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