Effects of d amphetamine and secobarbital on key press rates in normal humans

M. Stitzer, E. F. Domino

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of oral dexamphetame and (±)amphetamine 0.2 mg/kg and secobarbital 2 and 3 mg/kg were studied on key press responding in 8 normal human volunteers. Three rats of responding were generated with instructions and money as reinforcement in a 3 component multiple schedule. Rates were 2.1-14.6 (component 1), 29.3-49.9 (component 2) and 100.6-505 (component 3) responses/min. Pattern of responding within the minute was either steady responding or a pause after reinforcement followed by a burst of responses. Secobarbital consistently decreased high response rates in component 3 in 5 out of 8 subjects, but had no effect on lower response rates. Amphetamine in the dose given had no reliable effect on performance.

Original languageEnglish (US)
Pages (from-to)288-297
Number of pages10
JournalArchives internationales de pharmacodynamie et de therapie
Volume207
Issue number2
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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