Effects of cyclosporine on human T cell activation

B. Ryffel, K. Tammi, A. Grieder, A. D. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

CyA had essentially no effect on the formation of IL-2 membrane receptors. Furthermore, the αTac-reactive cells displayed functional receptors, since a normal proliferative response to IL-2 was observed upon a short mitogenic pulse in the presence of CyA. Last, exogenous IL-2 reversed the inhibitory effect of CyA on T cell proliferation to a great extent. In confirmation of earlier reports, CyA inhibited the production of IL-2 of polyclonally stimulated T cells. Thus, the main inhibitory effect of CyA occurred at the level of IL-2 synthesis and/or release, whereas the formation of membrane receptors for IL-2 was not affected.

Original languageEnglish (US)
Pages (from-to)1268-1270
Number of pages3
JournalTransplantation proceedings
Volume17
Issue number1 II
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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