Effects of cycloalkyl ring analogs of phencyclidine on behavior in rodents

H. E. Shannon, R. L. McQuinn, D. B. Vaupel, E. J. Cone

Research output: Contribution to journalArticle

Abstract

The purpose of the present experiments was to evaluate the effects of eliminating or varying the size of the cycloalkyl ring of phencyclidine (PCP) from 3 to 8 carbons while leaving the composition of the benzene and piperidine rings unaltered. Compounds were evaluated for their effectiveness in producing PCP-like discriminative stimuli and changes in pupil diameter in the rat and impaired motor performance on the Rotarod in the mouse. All modifications of the cycloalkyl ring of PCP significantly reduced the relative potencies of the cycloalkyl analogs, shortened their duration of action and also modified their spectra of action, including their effectiveness in producing PCP-like discriminative stimuli and miosis in the rat as well as ataxia in the mouse. The present results demonstrate that the cyclohexyl moiety of PCP is an absolute requirement for producing a full PCP-like spectrum of activity.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume224
Issue number2
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Shannon, H. E., McQuinn, R. L., Vaupel, D. B., & Cone, E. J. (1983). Effects of cycloalkyl ring analogs of phencyclidine on behavior in rodents. Journal of Pharmacology and Experimental Therapeutics, 224(2), 327-333.