Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects

Jing Wang, Jun Song, Xiaohua Hou, Jinsong Liu, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Goals: The aim of this study was to investigate the therapeutic potential of cutaneous gastric electrical stimulation (CGES) at a tachygastrial frequency for obesity. Background: Implantable gastric electrical stimulator has been proposed for the treatment of obesity and it has recently been reported that the gastric electrical stimulation at a tachygastrial frequency inhibits gastric motility. STUDY Methods: Ten lean and 10 obese healthy volunteers were studied in 3 randomized sessions: no CGES, CGES at the physiologic frequency (3cycles/min), and CGES at tachygastrial frequency (12cycles/min). Electrical stimulation was performed using sinusoidal waves. The protocol included the following sequence: 20-minute baseline, 30-minute CGES, 30-minute recording without CGES, 30-minute CGES, ingestion of a 500kcal liquid meal, and 30-minute CGES. Gastric slow waves were recorded using cutaneous electrogastrography during the periods without CGES. Gastric emptying was assessed by ultrasound. Dyspeptic symptoms were recorded. Results: (1) The half-time of gastric emptying was longer with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean subjects (75.0±16.5min vs. 41.0±8.7min, P<0.01) and obese subjects (64.1±13.3min vs. 32.7±5.0min, P<0.01). (2) Postprandial dyspeptic symptom score (mainly satiety and fullness) was significantly higher with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean (3.2±1.47 vs. 1.7±0.94, P<0.01) and obese (3.9±1.89 vs. 1.8±1.15, P<0.01) subjects. Conclusions: CGES at a tachygastrial frequency enhances postprandial fullness and satiety, and delays gastric emptying. Its therapeutic potential for obesity needs to be studied.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalJournal of clinical gastroenterology
Volume44
Issue number5
DOIs
StatePublished - May 2010

Keywords

  • Gastric electric stimulation
  • Gastric emptying
  • Gastric myoelectrical activity
  • Gastric slow waves
  • Obesity

ASJC Scopus subject areas

  • Gastroenterology

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