Effects of conjunctival resection on the corneal immune response

Khalid F. Tabbara, Show Sakuragi, Joan Hall, Brigitte Frey

Research output: Contribution to journalArticle

Abstract

In order to evaluate the effect of perilimbal conjunctival resection on the corneal immune response, we immunized rabbits with either intravenous or topical administration of bovine gamma globulin. After unilateral perilimbal conjunctival resection, the corneas were challenged with intracorneal injections of bovine gamma globulin. Perilimbal conjunctival resection prevented the development of peripheral corneal infiltrates in the rabbits immunized intravenously (P <.0016) but not in those immunized topically. All- the animals developed antibody titers to bovine gamma globulin. Similarly, perilimbal conjunctival resection did not prevent corneal graft rejection in rabbits sensitized to their donors by previous skin grafting.

Original languageEnglish (US)
Pages (from-to)388-394
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume94
Issue number3
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Tabbara, K. F., Sakuragi, S., Hall, J., & Frey, B. (1982). Effects of conjunctival resection on the corneal immune response. American Journal of Ophthalmology, 94(3), 388-394.