Effects of combined electrical stimulation of the dorsal column and dorsal roots on wide-dynamic-range neuronal activity in nerve-injured rats

Fei Yang, Tong Zhang, Vinod Tiwari, Bin Shu, Chen Zhang, Yun Wang, Louis P. Vera-Portocarrero, Srinivasa N. Raja, Yun Guan

Research output: Contribution to journalArticle

Abstract

Objectives Electrical stimulation at the dorsal column (DC) and dorsal root (DR) may inhibit spinal wide-dynamic-range (WDR) neuronal activity in nerve-injured rats. The objective of this study was to determine if applying electrical conditioning stimulation (CS) at both sites provides additive or synergistic benefits. Materials and Methods By conducting in vivo extracellular recordings of WDR neurons in rats that had undergone L5 spinal nerve ligation, we tested whether combining 50 Hz CS at the two sites in either a concurrent (2.5 min) or alternate (5 min) pattern inhibits WDR neuronal activity better than CS at DC alone (5 min). The intensities of CS were determined by recording antidromic compound action potentials to graded stimulation at the DC and DR. We measured the current thresholds that resulted in the first detectable Aα/β waveform (Ab0) and the peak Aα/β waveform (Ab1) to select CS intensity at each site. The same number of electrical pulses and amount of current were delivered in different patterns to allow comparison. Results At a moderate intensity of 50% (Ab0 + Ab1), different patterns of CS all attenuated the C-component of WDR neurons in response to graded intracutaneous electrical stimuli (0.1-10 mA, 2 msec) and inhibited windup in response to repetitive noxious stimuli (0.5 Hz). However, the inhibitory effects did not differ significantly between different patterns. At the lower intensity (Ab0), no CS inhibited WDR neurons. Conclusions These findings suggest that combined stimulation of DC and DR may not be superior to DC stimulation alone for inhibition of WDR neurons.

Original languageEnglish (US)
Pages (from-to)592-597
Number of pages6
JournalNeuromodulation
Volume18
Issue number7
DOIs
StatePublished - Oct 2015

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Keywords

  • Dorsal column
  • dorsal root
  • nerve injury
  • neurostimulation
  • wide-dynamic-range neurons

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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