Effects of cocaine on sensory motor function in baboons

Robert D. Hienz, Debra J. Spear, Joseph V. Brady, Danielle A. Bowers

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.

Original languageEnglish (US)
Pages (from-to)399-408
Number of pages10
JournalPharmacology, Biochemistry and Behavior
Volume45
Issue number2
DOIs
StatePublished - Jun 1993

Keywords

  • Baboon
  • Cocaine
  • Lever press
  • Psychophysical procedure
  • Reaction time
  • Threshold

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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