Abstract
The effects of cocaine and quinpirole were studied in baboons to determine whether quinpirole, a relatively selective D2/D3 dopamine agonist, produced effects similar to those of cocaine on perceptual and motor processes. To measure perceptual and motor function, three baboons were trained to discriminate differences between a standard vowel and four other synthetic vowels; response accuracy as well as response latencies, or 'reaction times', were measured following drug administrations. Cocaine reduced reaction times in two baboons, and did not affect reaction times in a third; on the other hand, quinpirole lengthened reaction times in a dose-dependent manner in all baboons. Cocaine and quinpirole also differed in the time course to produce the maximal reaction time effect following drug administration. Cocaine and quinpirole did not differ consistently in their perceptual effects, as indicated by similar changes in d', a signal-detection index of discriminability. These distinct profiles of effects for cocaine and quinpirole suggest differing neurochemical actions for these two drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 38-45 |
| Number of pages | 8 |
| Journal | Psychopharmacology |
| Volume | 134 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1997 |
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Keywords
- Baboon
- Cocaine
- Lever release
- Quinpirole
- Reaction time
- Speech sound
- Stimulus control
- Vowels
ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of cocaine and quinpirole on perceptual and motor functions in baboons. / Hienz, Robert D; Zarcone, Troy J.; Pyle, Danielle A.; Brady, Joseph V.
In: Psychopharmacology, Vol. 134, No. 1, 1997, p. 38-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of cocaine and quinpirole on perceptual and motor functions in baboons
AU - Hienz, Robert D
AU - Zarcone, Troy J.
AU - Pyle, Danielle A.
AU - Brady, Joseph V.
PY - 1997
Y1 - 1997
N2 - The effects of cocaine and quinpirole were studied in baboons to determine whether quinpirole, a relatively selective D2/D3 dopamine agonist, produced effects similar to those of cocaine on perceptual and motor processes. To measure perceptual and motor function, three baboons were trained to discriminate differences between a standard vowel and four other synthetic vowels; response accuracy as well as response latencies, or 'reaction times', were measured following drug administrations. Cocaine reduced reaction times in two baboons, and did not affect reaction times in a third; on the other hand, quinpirole lengthened reaction times in a dose-dependent manner in all baboons. Cocaine and quinpirole also differed in the time course to produce the maximal reaction time effect following drug administration. Cocaine and quinpirole did not differ consistently in their perceptual effects, as indicated by similar changes in d', a signal-detection index of discriminability. These distinct profiles of effects for cocaine and quinpirole suggest differing neurochemical actions for these two drugs.
AB - The effects of cocaine and quinpirole were studied in baboons to determine whether quinpirole, a relatively selective D2/D3 dopamine agonist, produced effects similar to those of cocaine on perceptual and motor processes. To measure perceptual and motor function, three baboons were trained to discriminate differences between a standard vowel and four other synthetic vowels; response accuracy as well as response latencies, or 'reaction times', were measured following drug administrations. Cocaine reduced reaction times in two baboons, and did not affect reaction times in a third; on the other hand, quinpirole lengthened reaction times in a dose-dependent manner in all baboons. Cocaine and quinpirole also differed in the time course to produce the maximal reaction time effect following drug administration. Cocaine and quinpirole did not differ consistently in their perceptual effects, as indicated by similar changes in d', a signal-detection index of discriminability. These distinct profiles of effects for cocaine and quinpirole suggest differing neurochemical actions for these two drugs.
KW - Baboon
KW - Cocaine
KW - Lever release
KW - Quinpirole
KW - Reaction time
KW - Speech sound
KW - Stimulus control
KW - Vowels
UR - http://www.scopus.com/inward/record.url?scp=0030678588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030678588&partnerID=8YFLogxK
U2 - 10.1007/s002130050423
DO - 10.1007/s002130050423
M3 - Article
C2 - 9399365
AN - SCOPUS:0030678588
VL - 134
SP - 38
EP - 45
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -