Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents

Wenzhen Duan, J. T. Zhang

Research output: Contribution to journalArticle

Abstract

Using radioligand binding assay, the effects of (-), (+) clausenamide on N-methyl-D-asparate(NMDA) receptor were studied in synaptic membrane, hippocampus and cerebral cortex in rats. The Bmax and KD values of NMDA receptor in mouse brain were measured with Scatchard plot method. Results showed that there was no specific binding of (-), (+) clausenamide to NMDA-receptor. However, higher Bmax values were observed in (-) clausenamide-treated rats than the control group, but no effect on KD value. (+) Clausenamide treatment showed no effect on Bmax and KD values. The findings suggest that the pharmacologic actions of clausenamide depends on its chirality. Up regulation of NMDA-receptor induced by (-) clausenamide is helpful to elucidate its nootropic mechanism.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalYaoxue Xuebao
Volume32
Issue number4
StatePublished - Apr 1997
Externally publishedYes

Fingerprint

Rodentia
Nootropic Agents
Pharmacologic Actions
Synaptic Membranes
Radioligand Assay
Cerebral Cortex
clausenamide
Hippocampus
Up-Regulation
Control Groups
Brain

Keywords

  • Clausenamide
  • N-methyl-D-asparate receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents. / Duan, Wenzhen; Zhang, J. T.

In: Yaoxue Xuebao, Vol. 32, No. 4, 04.1997, p. 259-263.

Research output: Contribution to journalArticle

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