Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents

W. Z. Duan; J. T. Zhang

Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents

Research output: Contribution to journal › Article › peer-review

Abstract

Using radioligand binding assay, the effects of (-), (+) clausenamide on N-methyl-D-asparate(NMDA) receptor were studied in synaptic membrane, hippocampus and cerebral cortex in rats. The Bmax and K_D values of NMDA receptor in mouse brain were measured with Scatchard plot method. Results showed that there was no specific binding of (-), (+) clausenamide to NMDA-receptor. However, higher Bmax values were observed in (-) clausenamide-treated rats than the control group, but no effect on K_D value. (+) Clausenamide treatment showed no effect on Bmax and K_D values. The findings suggest that the pharmacologic actions of clausenamide depends on its chirality. Up regulation of NMDA-receptor induced by (-) clausenamide is helpful to elucidate its nootropic mechanism.

Original language	English (US)
Pages (from-to)	259-263
Number of pages	5
Journal	Yaoxue Xuebao
Volume	32
Issue number	4
State	Published - Apr 1 1997
Externally published	Yes

Keywords

Clausenamide
N-methyl-D-asparate receptor

ASJC Scopus subject areas

Molecular Medicine
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents",

abstract = "Using radioligand binding assay, the effects of (-), (+) clausenamide on N-methyl-D-asparate(NMDA) receptor were studied in synaptic membrane, hippocampus and cerebral cortex in rats. The Bmax and KD values of NMDA receptor in mouse brain were measured with Scatchard plot method. Results showed that there was no specific binding of (-), (+) clausenamide to NMDA-receptor. However, higher Bmax values were observed in (-) clausenamide-treated rats than the control group, but no effect on KD value. (+) Clausenamide treatment showed no effect on Bmax and KD values. The findings suggest that the pharmacologic actions of clausenamide depends on its chirality. Up regulation of NMDA-receptor induced by (-) clausenamide is helpful to elucidate its nootropic mechanism.",

keywords = "Clausenamide, N-methyl-D-asparate receptor",

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year = "1997",

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T1 - Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents

AU - Duan, W. Z.

AU - Zhang, J. T.

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Y1 - 1997/4/1

N2 - Using radioligand binding assay, the effects of (-), (+) clausenamide on N-methyl-D-asparate(NMDA) receptor were studied in synaptic membrane, hippocampus and cerebral cortex in rats. The Bmax and KD values of NMDA receptor in mouse brain were measured with Scatchard plot method. Results showed that there was no specific binding of (-), (+) clausenamide to NMDA-receptor. However, higher Bmax values were observed in (-) clausenamide-treated rats than the control group, but no effect on KD value. (+) Clausenamide treatment showed no effect on Bmax and KD values. The findings suggest that the pharmacologic actions of clausenamide depends on its chirality. Up regulation of NMDA-receptor induced by (-) clausenamide is helpful to elucidate its nootropic mechanism.

AB - Using radioligand binding assay, the effects of (-), (+) clausenamide on N-methyl-D-asparate(NMDA) receptor were studied in synaptic membrane, hippocampus and cerebral cortex in rats. The Bmax and KD values of NMDA receptor in mouse brain were measured with Scatchard plot method. Results showed that there was no specific binding of (-), (+) clausenamide to NMDA-receptor. However, higher Bmax values were observed in (-) clausenamide-treated rats than the control group, but no effect on KD value. (+) Clausenamide treatment showed no effect on Bmax and KD values. The findings suggest that the pharmacologic actions of clausenamide depends on its chirality. Up regulation of NMDA-receptor induced by (-) clausenamide is helpful to elucidate its nootropic mechanism.

KW - Clausenamide

KW - N-methyl-D-asparate receptor

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Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in Rodents

Abstract

Keywords

ASJC Scopus subject areas

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