Effects of chronic ethanol feeding on enzymes of rat brain and liver mitochondria

Warren Douglas Reed; Esteban Mezey

doi:10.1016/0024-3205(72)90169-5

Effects of chronic ethanol feeding on enzymes of rat brain and liver mitochondria

Warren Douglas Reed, Esteban Mezey

School of Medicine

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10 Scopus citations

Abstract

The effect of ethanol feeding for 21 days on the activities of enzymes intimately associated with rat liver and brain mitochondrial membranes was studied. Ethanol feeding did not result in any significant changes in the activities of enzymes located in the mitochondria as follows: monoamine oxidase in the outer membrane, α-glycerolphosphate dehydrogenase in the outer side of the inner membrane, succinate dehydrogenase in the inner side of the inner membrane and malate dehydrogenase in the matrix. By contrast there were significant increases in microsomal cytochrome P-450, b₅, aniline hydroxylase and NADPH dependent ethanol oxidizing activity. This study shows that ethanol feeding which produces microsomal enzyme induction does not result in significant changes in mitochondrial membrane associated enzymes.

Original language	English (US)
Pages (from-to)	847-857
Number of pages	11
Journal	Life Sciences
Volume	11
Issue number	17 PART 2
DOIs	https://doi.org/10.1016/0024-3205(72)90169-5
State	Published - Sep 8 1972

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "The effect of ethanol feeding for 21 days on the activities of enzymes intimately associated with rat liver and brain mitochondrial membranes was studied. Ethanol feeding did not result in any significant changes in the activities of enzymes located in the mitochondria as follows: monoamine oxidase in the outer membrane, α-glycerolphosphate dehydrogenase in the outer side of the inner membrane, succinate dehydrogenase in the inner side of the inner membrane and malate dehydrogenase in the matrix. By contrast there were significant increases in microsomal cytochrome P-450, b5, aniline hydroxylase and NADPH dependent ethanol oxidizing activity. This study shows that ethanol feeding which produces microsomal enzyme induction does not result in significant changes in mitochondrial membrane associated enzymes.",

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AB - The effect of ethanol feeding for 21 days on the activities of enzymes intimately associated with rat liver and brain mitochondrial membranes was studied. Ethanol feeding did not result in any significant changes in the activities of enzymes located in the mitochondria as follows: monoamine oxidase in the outer membrane, α-glycerolphosphate dehydrogenase in the outer side of the inner membrane, succinate dehydrogenase in the inner side of the inner membrane and malate dehydrogenase in the matrix. By contrast there were significant increases in microsomal cytochrome P-450, b5, aniline hydroxylase and NADPH dependent ethanol oxidizing activity. This study shows that ethanol feeding which produces microsomal enzyme induction does not result in significant changes in mitochondrial membrane associated enzymes.

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Effects of chronic ethanol feeding on enzymes of rat brain and liver mitochondria

Abstract

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