The effect of ethanol feeding for 21 days on the activities of enzymes intimately associated with rat liver and brain mitochondrial membranes was studied. Ethanol feeding did not result in any significant changes in the activities of enzymes located in the mitochondria as follows: monoamine oxidase in the outer membrane, α-glycerolphosphate dehydrogenase in the outer side of the inner membrane, succinate dehydrogenase in the inner side of the inner membrane and malate dehydrogenase in the matrix. By contrast there were significant increases in microsomal cytochrome P-450, b5, aniline hydroxylase and NADPH dependent ethanol oxidizing activity. This study shows that ethanol feeding which produces microsomal enzyme induction does not result in significant changes in mitochondrial membrane associated enzymes.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)