Effects of cholinergic stimulation on pituitary hormone release

Bonnie M. Davis; Gregory M. Brown; Myron Miller; Henry G. Friesen; Abba J. Kastin; Kenneth L. Davis

doi:10.1016/0306-4530(82)90038-5

Effects of cholinergic stimulation on pituitary hormone release

Bonnie M. Davis, Gregory M. Brown, Myron Miller, Henry G. Friesen, Abba J. Kastin, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Physostigmine was infused into human volunteers to assess the effect of central cholinergic stimulation on memory and on neuroendocrine function. Methscopolamine bromide, a peripheral anticholinergic agent, was given simultaneously. The lower dose of physostigmine (1.0 mg) produced no change in AVP, cortisol, melatonin, GH or LH in those subjects without unpleasant cholinergic side effects. Larger doses of physostigmine usually produced nausea, and were associated with marked elevations of AVP, cortisol and prolactin, but no change in GH, LH or melatonin. Thus, cholinergic agents easily induce a stress response, but the GH component of this response can be suppressed by peripheral cholinergic blockade.

Original language	English (US)
Pages (from-to)	347-354
Number of pages	8
Journal	Psychoneuroendocrinology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0306-4530(82)90038-5
State	Published - 1982
Externally published	Yes

Keywords

Acetylcholine
cortisol
growth hormone
luteinizing hormone
melatonin
methscopolamine
physostigmine
prolactin
stress
vasopressin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/0306-4530(82)90038-5

Cite this

@article{dd086159f41d470cb32039f13dbac832,

title = "Effects of cholinergic stimulation on pituitary hormone release",

abstract = "Physostigmine was infused into human volunteers to assess the effect of central cholinergic stimulation on memory and on neuroendocrine function. Methscopolamine bromide, a peripheral anticholinergic agent, was given simultaneously. The lower dose of physostigmine (1.0 mg) produced no change in AVP, cortisol, melatonin, GH or LH in those subjects without unpleasant cholinergic side effects. Larger doses of physostigmine usually produced nausea, and were associated with marked elevations of AVP, cortisol and prolactin, but no change in GH, LH or melatonin. Thus, cholinergic agents easily induce a stress response, but the GH component of this response can be suppressed by peripheral cholinergic blockade.",

keywords = "Acetylcholine, cortisol, growth hormone, luteinizing hormone, melatonin, methscopolamine, physostigmine, prolactin, stress, vasopressin",

author = "Davis, {Bonnie M.} and Brown, {Gregory M.} and Myron Miller and Friesen, {Henry G.} and Kastin, {Abba J.} and Davis, {Kenneth L.}",

year = "1982",

doi = "10.1016/0306-4530(82)90038-5",

language = "English (US)",

volume = "7",

pages = "347--354",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Effects of cholinergic stimulation on pituitary hormone release

AU - Davis, Bonnie M.

AU - Brown, Gregory M.

AU - Miller, Myron

AU - Friesen, Henry G.

AU - Kastin, Abba J.

AU - Davis, Kenneth L.

PY - 1982

Y1 - 1982

N2 - Physostigmine was infused into human volunteers to assess the effect of central cholinergic stimulation on memory and on neuroendocrine function. Methscopolamine bromide, a peripheral anticholinergic agent, was given simultaneously. The lower dose of physostigmine (1.0 mg) produced no change in AVP, cortisol, melatonin, GH or LH in those subjects without unpleasant cholinergic side effects. Larger doses of physostigmine usually produced nausea, and were associated with marked elevations of AVP, cortisol and prolactin, but no change in GH, LH or melatonin. Thus, cholinergic agents easily induce a stress response, but the GH component of this response can be suppressed by peripheral cholinergic blockade.

AB - Physostigmine was infused into human volunteers to assess the effect of central cholinergic stimulation on memory and on neuroendocrine function. Methscopolamine bromide, a peripheral anticholinergic agent, was given simultaneously. The lower dose of physostigmine (1.0 mg) produced no change in AVP, cortisol, melatonin, GH or LH in those subjects without unpleasant cholinergic side effects. Larger doses of physostigmine usually produced nausea, and were associated with marked elevations of AVP, cortisol and prolactin, but no change in GH, LH or melatonin. Thus, cholinergic agents easily induce a stress response, but the GH component of this response can be suppressed by peripheral cholinergic blockade.

KW - Acetylcholine

KW - cortisol

KW - growth hormone

KW - luteinizing hormone

KW - melatonin

KW - methscopolamine

KW - physostigmine

KW - prolactin

KW - stress

KW - vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0020463739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020463739&partnerID=8YFLogxK

U2 - 10.1016/0306-4530(82)90038-5

DO - 10.1016/0306-4530(82)90038-5

M3 - Article

C2 - 6132424

AN - SCOPUS:0020463739

SN - 0306-4530

VL - 7

SP - 347

EP - 354

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

IS - 4

ER -

Effects of cholinergic stimulation on pituitary hormone release

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this