Effects of cholecystokinin on gallbladder stasis and cholesterol gallstone formation

Joel J. Roslyn, Lawrence Denbesten, Henry A. Pitt, Stephen Kuchenbecker, James W. Polarek

Research output: Contribution to journalArticle

Abstract

Recent studies suggest an etiologic role for gallbladder stasis in the genesis of cholesterol gallstones. The effect of periodic gallbladder emptying on stone prevention is not clear. Using the prairie dog model, we tested the hypothesis that daily cholecystokinin-octapeptide (CCK-OP) prevents gallbladder stasis and cholesterol gallstone formation. Prairie dogs were fed either a control or a 0.4% cholesterol-enriched chow for 6 weeks. Cholesterol-fed animals received a daily intramuscular injection of either saline, CCK-OP, 0.2 μg/kg or CCK-OP, 1.0 μg/kg. Gallbladder bile lithogenic index (LI), bile salt pool size (BSPS), and the degree of radioisotope equilibration between gallbladder and hepatic bile (Rsa-an index of stasis) were determined. The more physiologic dose of CCK-OP (0.2) significantly reduced BSPS and bile lithogenicity, prevented stasis and reduced the incidence of gallstones. Our data suggest that (1) periodic gallbladder emptying decreases bile lithogenicity, prevents stasis, and reduces the incidence of cholelithiasis, (2) stasis is essential to gallstone formation and (3) daily physiologic doses of CCK-OP may be useful for gallstone prophylaxis in high-risk patients.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of Surgical Research
Volume30
Issue number3
DOIs
StatePublished - 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Roslyn, J. J., Denbesten, L., Pitt, H. A., Kuchenbecker, S., & Polarek, J. W. (1981). Effects of cholecystokinin on gallbladder stasis and cholesterol gallstone formation. Journal of Surgical Research, 30(3), 200-204. https://doi.org/10.1016/0022-4804(81)90148-7